| + |
C11orf49 | up-regulates quantity by stabilization 
binding
|
Tubulin polyglutamylase complex |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280986 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34782749 |
Here we identified a novel regulator of the tubulin polyglutamylase complex (TPGC), C11ORF49/CSTPP1, that regulates cytoskeletal organization, nuclear shape, and cilium disassembly. Mechanistically, loss of C11ORF49/CSTPP1 impacts the assembly and stability of the TPGC, which modulates long-chain polyglutamylation levels on microtubules (MTs) and thereby balances the binding of MT-associated proteins and actin nucleators. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TPGS2 | form complex 
binding
|
Tubulin polyglutamylase complex |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280981 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34782749 |
Tubulin polyglutamylase complex (TPGC) was the first protein complex identified with tubulin polyglutamylase activity.12,13 TPGC is comprised of a catalytic subunit, tubulin tyrosine ligase-like 1 (TTLL1), and four additional subunits, tubulin polyglutamylase complex subunits 1 and 2 (TPGS1 and TPGS2), leucine rich repeat containing 49 (LRRC49), and nicolin 1 (NICN1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TTLL1 | form complex
binding
|
Tubulin polyglutamylase complex |
0.61 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280980 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34782749 |
Tubulin polyglutamylase complex (TPGC) was the first protein complex identified with tubulin polyglutamylase activity.12,13 TPGC is comprised of a catalytic subunit, tubulin tyrosine ligase-like 1 (TTLL1), and four additional subunits, tubulin polyglutamylase complex subunits 1 and 2 (TPGS1 and TPGS2), leucine rich repeat containing 49 (LRRC49), and nicolin 1 (NICN1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TPGS1 | form complex
binding
|
Tubulin polyglutamylase complex |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280982 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34782749 |
Tubulin polyglutamylase complex (TPGC) was the first protein complex identified with tubulin polyglutamylase activity.12,13 TPGC is comprised of a catalytic subunit, tubulin tyrosine ligase-like 1 (TTLL1), and four additional subunits, tubulin polyglutamylase complex subunits 1 and 2 (TPGS1 and TPGS2), leucine rich repeat containing 49 (LRRC49), and nicolin 1 (NICN1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRRC49 | form complex
binding
|
Tubulin polyglutamylase complex |
0.654 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280983 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34782749 |
Tubulin polyglutamylase complex (TPGC) was the first protein complex identified with tubulin polyglutamylase activity.12,13 TPGC is comprised of a catalytic subunit, tubulin tyrosine ligase-like 1 (TTLL1), and four additional subunits, tubulin polyglutamylase complex subunits 1 and 2 (TPGS1 and TPGS2), leucine rich repeat containing 49 (LRRC49), and nicolin 1 (NICN1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NICN1 | form complex
binding
|
Tubulin polyglutamylase complex |
0.605 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280984 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34782749 |
Tubulin polyglutamylase complex (TPGC) was the first protein complex identified with tubulin polyglutamylase activity.12,13 TPGC is comprised of a catalytic subunit, tubulin tyrosine ligase-like 1 (TTLL1), and four additional subunits, tubulin polyglutamylase complex subunits 1 and 2 (TPGS1 and TPGS2), leucine rich repeat containing 49 (LRRC49), and nicolin 1 (NICN1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Tubulin polyglutamylase complex | up-regulates 
|
Microtubule_polimerization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280985 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34782749 |
Tubulin polyglutamylation levels are maintained by the tubulin glutamylase family of tubulin tyrosine ligase-like (TTLL) proteins and the cytosolic carboxypeptidases (CCPs), a family of tubulin deglutamylases. Tubulin polyglutamylase complex (TPGC) was the first protein complex identified with tubulin polyglutamylase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Tubulin polyglutamylase complex