| + |
MATN3 | form complex 
binding
|
Matrilin-1 - Matrilin-3 complex |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281398 |
|
|
Homo sapiens |
HEK-293-EBNA Cell |
| pmid |
sentence |
| 10660556 |
Matrilin-3 is a recently identified member of the superfamily of proteins containing von Willebrand factor A-like domains and is able to form hetero-oligomers with matrilin-1 (cartilage matrix protein) via a C-terminal coiled-coil domain. Full-length matrilin-3 and a fragment lacking the assembly domain were expressed in 293-EBNA cells, purified, and subjected to biochemical characterization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MATN1 | form complex
binding
|
Matrilin-1 - Matrilin-3 complex |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281399 |
|
|
Homo sapiens |
HEK-293-EBNA Cell |
| pmid |
sentence |
| 10660556 |
Matrilin-3 is a recently identified member of the superfamily of proteins containing von Willebrand factor A-like domains and is able to form hetero-oligomers with matrilin-1 (cartilage matrix protein) via a C-terminal coiled-coil domain. Full-length matrilin-3 and a fragment lacking the assembly domain were expressed in 293-EBNA cells, purified, and subjected to biochemical characterization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Matrilin-1 - Matrilin-3 complex | down-regulates activity 
binding
|
BMP2 |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281400 |
|
|
Mus musculus |
Chondrocyte Cell Line |
| pmid |
sentence |
| 27104523 |
Binding of MATN3 with BMP-2 was determined by immunoprecipitation, solid phase binding, and surface plasmon resonance assays. In Matn3 KO mice, Smad1 activity was increased more in growth plate chondrocytes than in wild-type mice. Conversely, Matn3 overexpression in hypertrophic chondrocytes led to inhibition of Bmp-2-stimulated, BMP-responsive element-dependent Col X expression and Smad1 activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
Matrilin-1 - Matrilin-3 complex