Relation Results

Summary

Name ARDS
Primary ID SIGNOR-PH128
Type phenotype
Description acute respiratory distress syndrome (ARDS) is a de-vastating event, with an estimated mortality of approximately 40 %,defined as the presence of bilateral lung infiltrates and severe hypox-emia. ARDS can occur in a variety of clinical situations, includingpneumonia, sepsis, pancreatitis, blood transfusion. ARDS pathogenesisinvolves inflammatory injury to the alveolo–capillary membrane, whichresults in increased lung permeability and the exudation of protein-richpulmonary edema fluid into the airspaces, leading in the end to re-spiratory insufficiency PMID:32446778
Relations 9
Pathways SARS-CoV CYTOKINE STORM

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Type: Score: Layout: SPV 
0.70.70.70.70.70.70.70.70.7CCL2ARDSTNFIFNGImmune_responseCXCL8Macrophage_activationT_cell_activationInflammationCXCL10

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Relations
Regulator
Mechanism
target
score ℹ
+ CCL2up-regulates img/indirect-activation.png ARDS 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261032 Homo sapiens
pmid sentence
Taken together, these data clearly indicate that, in SARS-CoV in-fection, ARDS is the ultimate result of a cytokine storm. In this scenario,the release by immune effector cells of large amounts of pro-in-flammatory cytokines (IFNα, IFNγ, IL-1β, IL-6, IL-12, IL-18, IL-33,TNFα, TGFβ) and chemokines (CXCL10, CXCL8, CXCL9, CCL2, CCL3,CCL5) precipitates and sustains the aberrant systemic inflammatoryresponse. The cytokine storm is readily followed by theimmune system “attacking” the body, which in turn will cause ARDSand multiple organ failure, the final result being death, at least in themost severe cases of SARS-CoV-2 infection
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ TNFup-regulates img/indirect-activation.png ARDS 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261034 Homo sapiens
pmid sentence
Taken together, these data clearly indicate that, in SARS-CoV in-fection, ARDS is the ultimate result of a cytokine storm. In this scenario,the release by immune effector cells of large amounts of pro-in-flammatory cytokines (IFNα, IFNγ, IL-1β, IL-6, IL-12, IL-18, IL-33,TNFα, TGFβ) and chemokines (CXCL10, CXCL8, CXCL9, CCL2, CCL3,CCL5) precipitates and sustains the aberrant systemic inflammatoryresponse. The cytokine storm is readily followed by theimmune system “attacking” the body, which in turn will cause ARDSand multiple organ failure, the final result being death, at least in themost severe cases of SARS-CoV-2 infection
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ IFNGup-regulates img/indirect-activation.png ARDS 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261033 Homo sapiens
pmid sentence
Taken together, these data clearly indicate that, in SARS-CoV in-fection, ARDS is the ultimate result of a cytokine storm. In this scenario,the release by immune effector cells of large amounts of pro-in-flammatory cytokines (IFNα, IFNγ, IL-1β, IL-6, IL-12, IL-18, IL-33,TNFα, TGFβ) and chemokines (CXCL10, CXCL8, CXCL9, CCL2, CCL3,CCL5) precipitates and sustains the aberrant systemic inflammatoryresponse. The cytokine storm is readily followed by theimmune system “attacking” the body, which in turn will cause ARDSand multiple organ failure, the final result being death, at least in themost severe cases of SARS-CoV-2 infection
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ Immune_responseup-regulates img/indirect-activation.png ARDS 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261035 Homo sapiens
pmid sentence
The presence of SARS-CoV-2 in the lung induces an uncontrolled generalized immune response. Several immune cells (like T-lymphocytes, macrophages and dendritic cells) sustain the impressive secretion of cytokines and chemokines ultimately leading to acute respiratory distress syndrome. These data clearly indicate that, in SARS-CoV in-fection, ARDS is the ultimate result of a cytokine storm.
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ CXCL8up-regulates img/indirect-activation.png ARDS 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261030 Homo sapiens
pmid sentence
Taken together, these data clearly indicate that, in SARS-CoV in-fection, ARDS is the ultimate result of a cytokine storm. In this scenario,the release by immune effector cells of large amounts of pro-in-flammatory cytokines (IFNα, IFNγ, IL-1β, IL-6, IL-12, IL-18, IL-33,TNFα, TGFβ) and chemokines (CXCL10, CXCL8, CXCL9, CCL2, CCL3,CCL5) precipitates and sustains the aberrant systemic inflammatoryresponse. The cytokine storm is readily followed by theimmune system “attacking” the body, which in turn will cause ARDSand multiple organ failure, the final result being death, at least in themost severe cases of SARS-CoV-2 infection
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ Macrophage_activationup-regulates img/indirect-activation.png ARDS 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261021 Homo sapiens
pmid sentence
The presence of SARS-CoV-2 in the lung induces an uncontrolled generalized immune response. Several immune cells (like T-lymphocytes, macrophages and dendritic cells) sustain the impressive secretion of cytokines and chemokines ultimately leading to acute respiratory distress syndrome. These data clearly indicate that, in SARS-CoV in-fection, ARDS is the ultimate result of a cytokine storm.
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ T_cell_activationup-regulates img/indirect-activation.png ARDS 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261022 Homo sapiens
pmid sentence
The presence of SARS-CoV-2 in the lung induces an uncontrolled generalized immune response. Several immune cells (like T-lymphocytes, macrophages and dendritic cells) sustain the impressive secretion of cytokines and chemokines ultimately leading to acute respiratory distress syndrome. These data clearly indicate that, in SARS-CoV in-fection, ARDS is the ultimate result of a cytokine storm.
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ Inflammationup-regulates img/indirect-activation.png ARDS 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261036 Homo sapiens
pmid sentence
The presence of SARS-CoV-2 in the lung induces an uncontrolled generalized immune response. Several immune cells (like T-lymphocytes, macrophages and dendritic cells) sustain the impressive secretion of cytokines and chemokines ultimately leading to acute respiratory distress syndrome. These data clearly indicate that, in SARS-CoV in-fection, ARDS is the ultimate result of a cytokine storm.
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ CXCL10up-regulates img/indirect-activation.png ARDS 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261031 Homo sapiens
pmid sentence
Taken together, these data clearly indicate that, in SARS-CoV in-fection, ARDS is the ultimate result of a cytokine storm. In this scenario,the release by immune effector cells of large amounts of pro-in-flammatory cytokines (IFNα, IFNγ, IL-1β, IL-6, IL-12, IL-18, IL-33,TNFα, TGFβ) and chemokines (CXCL10, CXCL8, CXCL9, CCL2, CCL3,CCL5) precipitates and sustains the aberrant systemic inflammatoryresponse. The cytokine storm is readily followed by theimmune system “attacking” the body, which in turn will cause ARDSand multiple organ failure, the final result being death, at least in themost severe cases of SARS-CoV-2 infection
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
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