| + |
Platelet_alpha_granule_formation | up-regulates 
|
VWF |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261863 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| NBK559062 |
Exposed VWF bound to collagen from vascular injury and endothelial damage adheres to the GPIb receptor on platelets to initiate signaling pathways for platelet activation, the next step in primary hemostasis. VW|VWF released by Weibel-Palade bodies or alpha-granules can enter circulation or accumulate in the subendothelial matrix binding to collagen through its A3 domain. Once exposed under high shear stress conditions in the arterial circulation, VWF can bind to platelets via its A1 domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NBEAL2 | up-regulates
|
Platelet_alpha_granule_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261883 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 28082341 |
We compared platelet size and number of α-granules for two NBEAL2 and two GATA1-deficient patients and found reduced numbers of α-granules for all, with the defect being more pronounced for NBEAL2 deficiency. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Platelet_alpha_granule_formation