Relation Results

Summary

Name Platelet_alpha_granule_formation
Primary ID SIGNOR-PH136
Type phenotype
Description A process that is carried out at the cellular level which results in the assembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets.
Relations 2

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Type: Score: Layout: SPV 
0.70.7Platelet_alpha_granule_formationVWFNBEAL2

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Relations
Regulator
Mechanism
target
score ℹ
+ Platelet_alpha_granule_formationup-regulates img/indirect-activation.png VWF 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261863 Homo sapiens
pmid sentence
Exposed VWF bound to collagen from vascular injury and endothelial damage adheres to the GPIb receptor on platelets to initiate signaling pathways for platelet activation, the next step in primary hemostasis. VW|VWF released by Weibel-Palade bodies or alpha-granules can enter circulation or accumulate in the subendothelial matrix binding to collagen through its A3 domain. Once exposed under high shear stress conditions in the arterial circulation, VWF can bind to platelets via its A1 domain.
Publications: 1 Organism: Homo Sapiens
+ NBEAL2up-regulates img/indirect-activation.png Platelet_alpha_granule_formation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261883 Homo sapiens Blood Platelet
pmid sentence
We compared platelet size and number of α-granules for two NBEAL2 and two GATA1-deficient patients and found reduced numbers of α-granules for all, with the defect being more pronounced for NBEAL2 deficiency. 
Publications: 1 Organism: Homo Sapiens
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