| + |
F-actin_assembly | down-regulates 
|
Platelet_degranulation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266000 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 23805129 |
Inhibition of actin polymerization also augments the kinetics and degree of alpha-granule release (Flaumenhaft et al., 2005). These results suggest that F-actin disassembly might actually be required for normal granule secretion and that activation-mediated granule release is related to actin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STX11 | up-regulates 
|
Platelet_degranulation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261893 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22767500 |
In contrast to previous studies,13,15,16,19 the results of the present study show that syntaxin-2 and syntaxin-4 are not required for release, but that syntaxin-11 is critical for platelet exocytosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STX11-SNAP23 SNARE complex | up-regulates
|
Platelet_degranulation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261901 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22767500 |
Coimmunoprecipitation experiments showed that syntaxin-11 can form SNARE complexes with both VAMP-8 and SNAP-23. |The SNAREs form transmembrane complexes that mediate membrane fusion and granule cargo release. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STX11-VAMP8 SNARE complex | up-regulates
|
Platelet_degranulation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261902 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22767500 |
Coimmunoprecipitation experiments showed that syntaxin-11 can form SNARE complexes with both VAMP-8 and SNAP-23. |The SNAREs form transmembrane complexes that mediate membrane fusion and granule cargo release. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Platelet_degranulation