| + |
rRNA_transcription | up-regulates 
|
40S cytosolic small ribosomal subunit |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262601 |
|
|
|
|
| pmid |
sentence |
| 25901680 |
Here we report the near-atomic structure of the human ribosome derived from high-resolution single-particle cryo-electron microscopy and atomic model building. The structure has an average resolution of 3.6 Å, reaching 2.9 Å resolution in the most stable regions. |The human ribosome (80S) has a molecular weight of 4.3 MDa: the large subunit (60S) consists of 28S, 5S and 5.8S rRNAs and 47 proteins, while the small subunit (40S) possesses a single 18S rRNA chain and 33 pro- teins. |
|
| Publications: |
1 |
| + |
rRNA_transcription | up-regulates
|
39S mitochondrial large ribosomal subunit |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262600 |
|
|
|
|
| pmid |
sentence |
| 25838379 |
We have determined the structure of the intact mitoribosome to 3.5 angstrom resolution by means of single-particle electron cryogenic microscopy. It reveals 80 extensively interconnected proteins, 36 of which are specific to mitochondria, and three ribosomal RNA molecules. |
|
| Publications: |
1 |
| + |
rRNA_transcription | up-regulates
|
60S cytosolic large ribosomal subunit |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262602 |
|
|
|
|
| pmid |
sentence |
| 25901680 |
Here we report the near-atomic structure of the human ribosome derived from high-resolution single-particle cryo-electron microscopy and atomic model building. The structure has an average resolution of 3.6 Å, reaching 2.9 Å resolution in the most stable regions. |The human ribosome (80S) has a molecular weight of 4.3 MDa: the large subunit (60S) consists of 28S, 5S and 5.8S rRNAs and 47 proteins, while the small subunit (40S) possesses a single 18S rRNA chain and 33 pro- teins. |
|
| Publications: |
1 |
| + |
RNA Polymerase I | up-regulates
|
rRNA_transcription |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266177 |
|
|
|
|
| pmid |
sentence |
| 22260999 |
In eukaryotic cells, the RNA polymerase Pol I synthesizes the rRNA precursor, Pol II transcribes mRNAs and small non-coding RNAs (such as small nuclear RNAs), and Pol III produces tRNAs and other small RNAs. Pol I, II and II contain 14, 12 and 17 polypeptide subunits, respectively (Table 1). |
|
| Publications: |
1 |
| Pathways: | Transcription initiation |
| + |
MACROH2A1 | down-regulates 
|
rRNA_transcription |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272930 |
|
|
|
|
| pmid |
sentence |
| 16428466 |
These data unambiguously identify mH2A as a strong transcriptional repressor and show that the repressive effect of mH2A is realized on at least two different transcription activation chromatin-dependent pathways: histone acetylation and nucleosome remodeling. |
|
| Publications: |
1 |
| + |
rRNA_transcription | up-regulates
|
28S mitochondrial small ribosomal subunit |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262599 |
|
|
|
|
| pmid |
sentence |
| 25838379 |
We have determined the structure of the intact mitoribosome to 3.5 angstrom resolution by means of single-particle electron cryogenic microscopy. It reveals 80 extensively interconnected proteins, 36 of which are specific to mitochondria, and three ribosomal RNA molecules. |
|
| Publications: |
1 |
| + |
UBTF | up-regulates quantity by expression 
transcriptional regulation
|
rRNA_transcription |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262590 |
|
|
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 7877691 |
Rb specifically inhibits the activity of the RNA polymerase I transcription factor UBF (upstream binding factor) in vitro. |These results indicate that there is an additional mechanism by which Rb suppresses cell growth, namely that Rb directly represses transcription of the rRNA genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
| + |
PIN4 | up-regulates
|
rRNA_transcription |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265755 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12860119 |
Par14 is a pre-rRNA processing factor involved in mammalian ribosome biogenesis, Par14 deficiency slowed cell growth (Fig. 3A) and reduced the production of 18 and 28 S rRNAs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
rRNA_transcription