| + |
RAD21L Cohesin complex | up-regulates 
|
Meiotic_recombination |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264539 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21242291 |
RAD21L associates with SMC3, STAG3, and either SMC1α or SMC1β. Our results suggest that cohesin complexes containing RAD21L may be involved in synapsis initiation and crossover recombination between homologous chromosomes. In mice, RAD21L is expressed exclusively in early meiosis: it apparently replaces RAD21 in premeiotic S phase, becomes detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. RAD21L then disappears, and is replaced with RAD21. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Gonad |
| + |
MutSgamma meiotic recombination complex | up-regulates 
|
Meiotic_recombination |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281106 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 38348856 |
Msh4 and Msh5, collectively known as MutSγ, form a heterodimer that is structurally and functionally akin to the bacterial DNA mismatch repair factor MutS, which is characterised by its ring-like structure [118]. In vitro, studies demonstrate MutSγ’s preference for binding to double Holliday junctions (dHJs), though it generally exhibits high affinity for a variety of DNA repair intermediates [119,120]. This binding is believed to physically entrap two duplexes of double-stranded DNA, thereby stabilising the recombination intermediate. However, super-resolution microscopy data suggest that the Msh4/5 complex may only embrace one dsDNA in the recombination intermediate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Synaptonemal_complex | up-regulates
|
Meiotic_recombination |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264204 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33262143 |
The synaptonemal complex (SC) is a meiosis-specific structure formed between homologous chromosomes during prophase that promotes DSB formation and biases repair of DSBs to homologs over sister chromatids. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Meiotic_recombination