| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252165 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23973156 |
LIS1, the first gene to be identified as involved in a neuronal migration disease, is a dosage-sensitive gene whose proper levels are required for multiple aspects of cortical development. Deletions in LIS1 result in a severe brain malformation, known as lissencephaly, whereas duplications delay brain development. LIS1 affects the proliferation of progenitors, spindle orientation and interkinetic nuclear movement in the ventricular zone, as well as nucleokinesis and migration of neurons. |
|
3.0
Cerebral_cortex_development
