FAP: Adipogenic transcriptional cascade

Pathway ID: SIGNOR-FapATC

Description: Adipocyte differentiation is a highly orchestrated process. The best understood regulators of adipogenesis are the transcription factors that inhibit or promote this process. To date, over two dozen transcription factors have been shown to play a role in adipocyte development. While peroxisome proliferator-activated receptor gamma (PPARγ) is undoubtedly the most important transcriptional modulator of adipocyte development in all types of adipose tissue, members of the CCAAT/enhancer-binding protein, Krüppel-like transcription factor, signal transducer and activator of transcription, GATA, early B cell factor and interferon-regulatory factor families also regulate adipogenesis (Mota de Sa et al Compr Physiol. 2017 16;7(2):635-674).

Curated by: gcesareni

14 Seed Entities

Organism:
Name Primary ID
CEBPD P49716
RXRA P19793
SREBF1 P36956
KLF5 Q13887
NR3C1 P04150
GATA3 P23771
CREB1 P16220
PPARG P37231
Adipogenesis SIGNOR-PH26
CEBPB P17676
CEBPA P49715
FOXO1 Q12778
GATA2 P23769
RXRB P28702