Summary

Name RXRA
Full Name Retinoic acid receptor RXR-alpha
Synonyms Nuclear receptor subfamily 2 group B member 1, Retinoid X receptor alpha | NR2B1
Primary ID P19793
Links - -
Type protein
Relations 42
Pathways Acute Myeloid Leukemia, ASXL1 in AML, FAP: Adipogenic transcriptional cascade, Retinoic acid Signaling
Inhibitors [5-fluoro-1-(4-isopropylbenzylidene)-2-methylinden-3-yl]acetic acid; sulindac
Function Receptor for retinoic acid that acts as a transcription factor (PubMed:11162439, PubMed:11915042). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:28167758, PubMed:17761950, PubMed:16107141, PubMed:18800767, PubMed:19167885). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation RXRA 0.496
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RXRA 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation RXRA 0.438
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation RXRA 0.508
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RXRA 0.25
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RXRA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RXRA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARA 0.706
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML, Retinoic acid Signaling
+ up-regulates img/direct-activation.png binding THRB 0.707
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding THR 0.709
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.43
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Retinoic acid Signaling
+ up-regulates img/direct-activation.png binding RXRA 0.547
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RXRA 0.287
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ up-regulates img/direct-activation.png binding THRA 0.646
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARA 0.574
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARD 0.558
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CPT1B 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png chemical inhibition RXRA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding THR 0.709
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation RXRA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.285
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.479
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PML-RARalpha 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ up-regulates img/direct-activation.png binding RXRA 0.706
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML, Retinoic acid Signaling
+ up-regulates img/direct-activation.png binding RXRA 0.523
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RAR 0.706
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.666
Publications: 1 Organism: Homo Sapiens
Pathways:Retinoic acid Signaling
+ up-regulates img/direct-activation.png binding RXRA 0.785
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RXRA 0.438
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARG 0.666
Publications: 1 Organism: Homo Sapiens
Pathways:Retinoic acid Signaling
+ up-regulates img/direct-activation.png binding NR1H2 0.675
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RXRA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition RXRA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.66
Publications: 1 Organism: Homo Sapiens
Pathways:Retinoic acid Signaling
+ up-regulates activity img/direct-activation.png chemical activation RXRA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARG 0.725
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARB 0.66
Publications: 1 Organism: Homo Sapiens
Pathways:Retinoic acid Signaling