FAP: Wnt

Pathway ID: SIGNOR-FapWNT

Description: The non-canonical WNT ligand, WNT5A, binds frizzled (FZD2) receptor, hence activating the histone methyltransferase SET domain bifurcated 1 (SETDB1). SETDB1 forms a complex with chromodomain helicase DNA-binding 7 (CHD7) and NEMO-like kinase (NLK) to inhibit the ability of PPARγ to transcriptionally activate its downstream metabolic target genes. On the other hand, the canonical WNT ligand, WNT10B, inhibits adipocyte differentiation by leading off β-catenin nuclear translocation.

Curated by: Federica Ferrentino

14 Seed Entities

Organism:
Name Primary ID
GSK3B/Axin/APC SIGNOR-C110
TCF7L2 Q9NQB0
WNT5A P41221
FZD4 Q9ULV1
PPARG P37231
FZD1 Q9UP38
Adipogenesis SIGNOR-PH26
SOX6 P35712
FZD2 Q14332
CTNNB1 P35222
LRP6 O75581
MEST Q5EB52
DVL1 O14640
WNT10B O00744