Macrophage: TGF beta

Pathway ID: SIGNOR-MT

Description: Transforming growth factor-fl (TGF-fl) superfamily signaling plays a critical role in the regulation of cell growth, differentiation, and development in a wide range of biological systems. TGFb binds its receptor with the subsequent phosphorylation of the cytoplasmic signaling molecules Smad2 and Smad3. Carboxy-terminal phosphorylation of Smads by activated receptors results in their partnering with the common signaling transducer Smad4, and translocation to the nucleus. Activated Smads regulate diverse biological effects by partnering with transcription factors resulting in cell-state specific modulation of transcription.

Curated by: Alessandro Palma

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

9 Seed Entities

Organism:
Name Primary ID
M2 polarization SIGNOR-PH55
SMAD2 Q15796
SMAD2/SMAD4 SIGNOR-C8
SMAD3 P84022
SMAD3/SMAD4 SIGNOR-C9
SMAD4 Q13485
TGFB1 P01137
TGFBR1 P36897
ZFYVE9 O95405