The SIGnaling Network
Open Resource

Pathway ID: SIGNOR-MT

Description: Transforming growth factor beta (TGF-beta) superfamily signaling plays a critical role in the regulation of cell growth, differentiation and development in a wide range of biological systems. TGFb binds its receptor with the subsequent phosphorylation of the cytoplasmic signaling molecules SMAD2 and SMAD3. Carboxy-terminal phosphorylation of Smads by activated receptors results in their partnering with the common signaling transducer SMAD4, and translocation into the nucleus. Activated Smads regulate diverse biological effects by partnering with transcription factors resulting in cell-state specific modulation of transcription.

Curated by: Alessandro Palma