Summary

Name ZFYVE9
Full Name Zinc finger FYVE domain-containing protein 9
Synonyms Mothers against decapentaplegic homolog-interacting protein, Madh-interacting protein, Novel serine protease, NSP, Receptor activation anchor, hSARA, Smad anchor for receptor activation | MADHIP, SARA, SMADIP
Primary ID O95405
Links - -
Type protein
Relations 7
Pathways Macrophage: TGF beta, TGF-beta Signaling
Function Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.

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Relations

Regulator Mechanism target score ℹ
+ PMLup-regulates img/direct-activation.png binding ZFYVE9 0.551
Publications: 1 Organism: Homo Sapiens
+ TGFBR1up-regulates activity img/direct-activation.png binding ZFYVE9 0.613
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ ZFYVE9up-regulates activity img/direct-activation.png relocalization, binding SMAD3 0.852
Publications: 3 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ TGFBR2up-regulates activity img/direct-activation.png binding ZFYVE9 0.547
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ ZFYVE9up-regulates activity img/direct-activation.png relocalization SMAD2 0.904
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling