3.0
Macrophage: IFN gamma
Pathway ID: SIGNOR-MacroIFNG
Description: The inflammatory cytokine interferon gamma (IFNG) is produced following skeletal muscle injury and promotes efficient muscle healing. IFN gamma can drive macrophage polarization towards an M1 inflammatory phenotype. In particular, IFN-gamma interacts with a heterodimeric receptor, which in turn activates the JAK/STAT pathway, leading to M1 polarization of macrophages and the transcription of several downstream genes.
Curated by: Alessandro Palma
Description: The inflammatory cytokine interferon gamma (IFNG) is produced following skeletal muscle injury and promotes efficient muscle healing. IFN gamma can drive macrophage polarization towards an M1 inflammatory phenotype. In particular, IFN-gamma interacts with a heterodimeric receptor, which in turn activates the JAK/STAT pathway, leading to M1 polarization of macrophages and the transcription of several downstream genes.
Curated by: Alessandro Palma
13 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| M1_polarization | SIGNOR-PH54 |
| IFNGR2/INFGR1 | SIGNOR-C142 |
| NOS2 | P35228 |
| CIITA | P33076 |
| JAK1 | P23458 |
| nitric oxide | CHEBI:16480 |
| IFNG | P01579 |
| JAK2 | O60674 |
| SOCS1 | O15524 |
| MMP13 | P45452 |
| L-citrulline | CID:9750 |
| STAT1 | P42224 |
| STAT6 | P42226 |