Summary

Name CIITA
Full Name MHC class II transactivator
Synonyms CIITA | MHC2TA
Primary ID P33076
Links - -
Type protein
Relations 38
Pathways Satellite: IFN gamma, T-Lymphocyte: IL4 and its transcriptional regulation
Function Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation CIITA 0.312
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CIITA 0.348
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CIITA 0.446
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIITA 0.446
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIITA 0.348
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CIITA 0.352
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation S100A4 0.333
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-C 0.451
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MYOG 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRB3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIITA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png deacetylation CIITA 0.425
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation CIITA 0.524
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates img/indirect_inhibition.png transcriptional regulation IL4 0.422
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIITA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DOA 0.346
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DMA 0.418
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DMB 0.363
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DOB 0.319
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-E 0.472
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png transcriptional regulation CIITA 0.524
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-A 0.497
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CIITA 0.438
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRB1 0.514
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CIITA 0.503
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRB5 0.443
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png transcriptional regulation HLA-G 0.456
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRA 0.603
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-F 0.45
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DPB1 0.486
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DQB1 0.494
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CIITA 0.524
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HLA-DRB4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RFX5 0.757
Publications: 1 Organism: Homo Sapiens