3.0
Macrophage: IL4
Pathway ID: SIGNOR-MacroIL4
Description: Interleukin-4 (IL4) is a cytokine produced by T-helper cells, mast cells, basophils and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. IL4 is capable of exerting its biological activities through interaction with two cell surface receptor complexes - Type I IL4 receptor and Type II IL4 Receptor. The Type I receptors activate JAK1 and 3. The activated JAK phosphorylates tyrosine residues of the cytoplasmic tails of the receptor which then serve as docking sites for a number of adaptor or signaling molecules including STAT6. Activated STAT6 dimerizes, translocates into the nucleus and transcriptionally actives genes responsive to IL4.
Curated by: Alessandro Palma
Description: Interleukin-4 (IL4) is a cytokine produced by T-helper cells, mast cells, basophils and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. IL4 is capable of exerting its biological activities through interaction with two cell surface receptor complexes - Type I IL4 receptor and Type II IL4 Receptor. The Type I receptors activate JAK1 and 3. The activated JAK phosphorylates tyrosine residues of the cytoplasmic tails of the receptor which then serve as docking sites for a number of adaptor or signaling molecules including STAT6. Activated STAT6 dimerizes, translocates into the nucleus and transcriptionally actives genes responsive to IL4.
Curated by: Alessandro Palma
13 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| IRF4 | Q15306 |
| NfKb-p65/p50 | SIGNOR-C13 |
| M1_polarization | SIGNOR-PH54 |
| IL4 | P05112 |
| IL4R | P24394 |
| PPARG | P37231 |
| M2_polarization | SIGNOR-PH55 |
| KDM6B | O15054 |
| IL13 | P35225 |
| JAK2 | O60674 |
| SOCS1 | O15524 |
| STAT3 | P40763 |
| STAT6 | P42226 |