T-Lymphocyte: TGF beta

Pathway ID: SIGNOR-TLymphTGFB

Description: Transforming growth factor-beta1 (TGF-beta1) is able to convert naive T cells into regulatory T cells. TGF-beta acts by binding TGF-beta receptor 1, through the activation of SMAD3, which in turn enhances the expression of FOXP3 master gene.

Curated by: Alessandro Palma

18 Seed Entities

Organism:
Name Primary ID
IL17A Q16552
PIAS3 Q9Y6X2
SMAD3/PIAS3 SIGNOR-C204
TGFB1 P01137
JUN P05412
SMAD2/STAT3/EP300 SIGNOR-C203
FOXP3 Q9BZS1
Th17 SIGNOR-PH94
SMAD2 Q15796
RORC P51449
T-reg_differentiation SIGNOR-PH91
EP300 Q09472
TGFBR2 P37173
ERK1/2 SIGNOR-PF1
STAT5A P42229
STAT3 P40763
SMAD3 P84022
TGFBR1 P36897