3.0
GABAergic synapse
Pathway ID: SIGNOR-GSP
Description: Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). GABA binds to ionotropic GABA(a) receptors that mediate fast GABA responses by triggering chloride channel openings and metabotropic GABA(b) receptor that trigger slower responses by activating G-proteins and influencing second messenger systems. Glycine exerts its inhibitory effects via specific glycine receptors (GlyRs) anion channel and the resulting influx of Cl− ions hyperpolarizes the postsynaptic cell, thereby inhibiting neuronal firing.
Curated by: Marta Iannuccelli
Description: Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). GABA binds to ionotropic GABA(a) receptors that mediate fast GABA responses by triggering chloride channel openings and metabotropic GABA(b) receptor that trigger slower responses by activating G-proteins and influencing second messenger systems. Glycine exerts its inhibitory effects via specific glycine receptors (GlyRs) anion channel and the resulting influx of Cl− ions hyperpolarizes the postsynaptic cell, thereby inhibiting neuronal firing.
Curated by: Marta Iannuccelli
24 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| GlyR | SIGNOR-PF62 |
| Excitatory_synaptic_transmission | SIGNOR-PH133 |
| NLGN2 | Q8NFZ4 |
| CACNA1B | Q00975 |
| 3',5'-cyclic AMP | CHEBI:17489 |
| CREB1 | P16220 |
| GABARAP | O95166 |
| GABA-A | SIGNOR-PF61 |
| gamma-aminobutyric acid | CHEBI:16865 |
| ADCY1 | Q08828 |
| calcium(2+) | CHEBI:29108 |
| GNB/GNG | SIGNOR-C202 |
| BDNF | P23560 |
| GABA-B receptor | SIGNOR-C336 |
| Synaptic_plasticity | SIGNOR-PH158 |
| PKA | SIGNOR-PF17 |
| glycine | CHEBI:15428 |
| ARHGEF9 | O43307 |
| GNB5 | O14775 |
| chloride | CHEBI:17996 |
| SLC12A2 | P55011 |
| SLC12A5 | Q9H2X9 |
| AP-2 complex | SIGNOR-C245 |
| GPHN | Q9NQX3 |