Summary

Name GPHN
Full Name Gephyrin [Includes: Molybdopterin adenylyltransferase
Synonyms GEPH_HUMAN | GPH, KIAA1385
Primary ID Q9NQX3
Links - -
Type protein
Relations 7
Pathways GABAergic synapse
Function Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation GPHN 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation GPHN 0.289
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png binding ARHGEF9 0.631
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ up-regulates activity img/direct-activation.png binding NLGN2 0.495
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ up-regulates activity img/direct-activation.png binding GPHN 0.584
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ up-regulates quantity by stabilization img/direct-activation.png binding GABA-A 0.2
Publications: 1 Organism: Rattus Norvegicus
Pathways:GABAergic synapse