Relation Results

Summary

Name ARHGEF9
Full Name Rho guanine nucleotide exchange factor 9
Synonyms Collybistin, PEM-2 homolog, Rac/Cdc42 guanine nucleotide exchange factor 9 | ARHDH9, KIAA0424
Primary ID O43307
Links - -
Type protein
Relations 3
Pathways GABAergic synapse
Function Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity).

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Type: Score: Layout: SPV 
0.8340.70.609ARHGEF9CDC42Synaptic_plasticityGPHN

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Relations
Regulator
Mechanism
target
score ℹ
+ ARHGEF9up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.834
Identifier Residue Sequence Organism Cell Line
SIGNOR-260534 Homo sapiens HEK-293 Cell
pmid sentence
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2).
Publications: 1 Organism: Homo Sapiens
+ ARHGEF9up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264976 Homo sapiens Neuron
pmid sentence
Gephyrin is believed to act as a scaffold at inhibitory synapses, in a manner analogous to that of the prototypic excitatory synaptic scaffold, PSD-95. The best-known function of gephyrin is to bring the inhibitory synaptic receptors and to stabilize them at the inhibitory synapses. gephyrin interacts with NL-2 and collybistin, suggesting that it may be critical for the maturation or maintenance of inhibitory synapses.
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ GPHNup-regulates activity img/direct-activation.png binding ARHGEF9 0.609
Identifier Residue Sequence Organism Cell Line
SIGNOR-264973 Homo sapiens
pmid sentence
Gephyrin is believed to act as a scaffold at inhibitory synapses, in a manner analogous to that of the prototypic excitatory synaptic scaffold, PSD-95. The best-known function of gephyrin is to bring the inhibitory synaptic receptors and to stabilize them at the inhibitory synapses. gephyrin interacts with NL-2 and collybistin, suggesting that it may be critical for the maturation or maintenance of inhibitory synapses.
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
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