Satellite: Myogenic transcriptional cascade

Pathway ID: SIGNOR-ScMTC

Description: Upstream regulators of myogenesis establish a complex gene regulatory network that affects the muscle satellite cells fate. The expression of several transcription factors that take part into this network can lead to the activation, proliferation or differentiation of satellite cells. One important step is the MYOD up-regulation after satellite cell activation, that induces MYOG mRNA transcription and reduction of PAX7 protein levels, leading to the differentiation cascade of satellite cells.

Curated by: Simone Vumbaca

10 Seed Entities

Organism:
Name Primary ID
MEF2A Q02078
MYF5 P13349
MYOD1 P15172
Proliferation SIGNOR-PH4
MEF2D Q14814
Skeletal_muscle_differentiation SIGNOR-PH1
MYF6 P23409
MEF2C Q06413
PAX7 P23759
MYOG P15173