| + |
MYOD1 | up-regulates quantity by expression 
transcriptional regulation
|
MYOG |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135984 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15870273 |
We observed that the homeodomain factor pbx1, which cooperates with myod to stimulate myogenin expression, is constitutively bound to the myogenin promoter in a swi/snf-independent manner, suggesting a two-step mechanism in which myod initially interacts indirectly with the myogenin promoter and attracts chromatin-remodeling enzymes, which then facilitate direct binding by myod and other regulatory proteins. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235009 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18676376 |
provide a novel transcriptional paradigm for the first steps of myogenesis, where a calcineurin/NFATc3 pathway regulates myogenin induction in cooperation with MyoD during myogenesis. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma |
| + |
CDK4 | down-regulates 
binding
|
MYOG |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176530 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
In contrast to cdk2, cyclin d/cdk4 blocks myod activity through an as yet unclear mechanism that may involve direct binding. Cyclin d/cdk4 can also block the activity of myogenin and all mef2 isoforms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDFI | down-regulates activity
binding
|
MYOG |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240493 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8797820 |
We demonstrate that I-mf inhibits the transactivation activity of the MyoD family and represses myogenesis. I-mf associates with MyoD family members and retains them in the cytoplasm by masking their nuclear localization signals. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
JARID2 | down-regulates quantity by repression
transcriptional regulation
|
MYOG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249599 |
|
|
Homo sapiens |
Rhabdomyosarcoma Cell Line |
| pmid |
sentence |
| 23435416 |
JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells|Addition of Differentiation Media (DM) to human myoblasts was associated with the induction of MYOG, MYOD and MYL1 and a decrease in JARID2 RNA expression|Furthermore, we that showed JARID2 binds to and alters the methylation status of histone H3 lysine 27 in the promoter regions of MYOG and MYL1 and that the interaction of JARID2 at these promoters is dependent upon EED, a core component of the Polycomb Repressive Complex 2 (PRC2). Therefore JARID2 is a downstream effector of PAX3-FOXO1 that maintains an undifferentiated myogenic phenotype that is characteristic of RMS |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SUV39H1 | down-regulates quantity by repression 
transcriptional regulation
|
MYOG |
0.415 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249601 |
|
|
Homo sapiens |
Rhabdomyosarcoma Cell Line |
| pmid |
sentence |
| 23435416 |
The methyl marks H3K9me3 on the myoD promoter and H3K27me3 on the myogenin promoter have been shown to be under the control of the histone methyl transferase KMT1A and the HDM KDM4A, respectively, during normal myogenesis. In addition, KMT1A has recently been shown to play a role in ARMS by inhibiting myogenic differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNHIT1 | up-regulates quantity by expression 
transcriptional regulation
|
MYOG |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165613 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20473270 |
We show that the srcap subunit named znhit1 or p18hamlet, which is a substrate of p38 mapk, is recruited to the myogenin promoter at the onset of muscle differentiation, in a p38 mapk-dependent manner. We also show that p18hamlet is required for h2a.z accumulation into this genomic region and for subsequent muscle gene transcriptional activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMARCD3 | up-regulates quantity by expression
transcriptional regulation
|
MYOG |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-136945 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15870273 |
We observed that the homeodomain factor pbx1, which cooperates with myod to stimulate myogenin expression, is constitutively bound to the myogenin promoter in a swi/snf-independent manner, suggesting a two-step mechanism in which myod initially interacts indirectly with the myogenin promoter and attracts chromatin-remodeling enzymes, which then facilitate direct binding by MyoD and other regulatory proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MYOG | form complex 
binding
|
Myog/SWI/SNF complex |
0.633 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151691 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17194702 |
Upon the expression of myogenin, myogenin, mef2d, and brg1 localize to the myogenin promoter to maintain myogenin expression./ Swi/snf chromatin-remodeling activity is required for myogenin expression in differentiated skeletal muscle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
MYOG | up-regulates quantity
transcriptional regulation
|
mir-133a2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255919 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18619954 |
We found that directed expression of MRFs in the neural tube of chicken embryos induced ectopic expression of miR-1 and miR-206. Conversely, the lack of Myf5 but not of MyoD resulted in a loss of miR-1 and miR-206 expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYOG | up-regulates
|
Skeletal_muscle_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37461 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8288123 |
The myogenic regulators myod, myogenin, myf5, and mrf4 share -80% amino acid identity within a basic helix-loop--helix (bhlh) motif that mediates dimerization and dna binding. / myogenic bhlh proteins form heterodimers with ubiquitous bhlh proteins, known as e proteins, and activate the transcription of muscle-specific genes by binding to the e-box consensus sequence (canntg) in muscle gene promoters and enancers. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255112 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28163303 |
During early stages of myogenesis, CIITA binds directly to myogenin (MYOG) and inactivates it, preventing MYOG-mediated induction of myogenic genes that are required for muscle differentiation and function |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma |
| + |
MYOD1 | up-regulates quantity by expression
transcriptional regulation
|
MYOG |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255639 |
|
|
|
|
| pmid |
sentence |
| 15870273 |
We suggest that the interaction between MyoD and Pbx is necessary to initially target MyoD to the myogenin promoter |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255640 |
|
|
|
|
| pmid |
sentence |
| 12694204 |
We conclude that MyoD is the major MRF that binds to the E-box from the myogenin promoter during differentiation. |
|
| Publications: |
2 |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma |
| + |
MYOG | down-regulates quantity by repression
transcriptional regulation
|
CDKN1A |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251575 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25211658 |
P21 is regulated by MyoD and myogenin in normal muscle cells and the inactivation of these factors in RMS cells contributes to the silencing of p21 in RMS cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
CyclinD/CDK4 | down-regulates
binding
|
MYOG |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216972 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
In contrast to cdk2, cyclin d/cdk4 blocks myod activity through an as yet unclear mechanism that may involve direct binding. Cyclin d/cdk4 can also block the activity of myogenin and all mef2 isoforms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis, Rhabdomyosarcoma |
| + |
MYOG | up-regulates
binding
|
SWI/SNF complex |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217740 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17194702 |
Upon the expression of myogenin, myogenin, mef2d, and brg1 localize to the myogenin promoter to maintain myogenin expression./ Swi/snf chromatin-remodeling activity is required for myogenin expression in differentiated skeletal muscle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
NFIA | up-regulates quantity by expression
transcriptional regulation
|
MYOG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263983 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32991581 |
NFIA binds to and activates the brown-fat-specific enhancers even before differentiation and later facilitates the binding of PPARgamma|NFIA has at least three functions on the transcriptional regulation of brown fat [2]. First, NFIA activates adipogenesis per se, through activating the transcription of Pparg, which encodes PPARgamma. Second, NFIA also activates the brown-fat-specific gene expression (such as Ucp1 and Ppargc1a) independent of the degree of adipocyte differentiation, through facilitating the binding of PPARgamma to the brown-fat-specific enhancers. Third, NFIA represses myogenesis through suppression of myogenic transcription factors such as Myod1 as well as Myog, |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYOG | up-regulates quantity
|
mir-133a1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256309 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18568019 |
In leukaemic cell lines PLZF overexpression downmodulated miR-146a and upregulated CXCR4 protein, whereas PLZF knockdown induced the opposite effects. Our data indicate that megakaryopoiesis is controlled by a cascade pathway, in which PLZF suppresses miR-146a transcription and thereby activates CXCR4 translation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX2 | down-regulates activity
binding
|
MYOG |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251561 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24470334 |
We have found that TBX2 is highly up regulated in both ERMS and ARMS subtypes of RMS and demonstrate that TBX2 is a repressor of myogenesis by binding to MyoD and myogenin and inhibiting their activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Rhabdomyosarcoma |
| + |
MYOG | up-regulates
transcriptional regulation
|
MYOG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151694 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17194702 |
Upon the expression of myogenin, myogenin, mef2d, and brg1 localize to the myogenin promoter to maintain myogenin expression./ Swi/snf chromatin-remodeling activity is required for myogenin expression in differentiated skeletal muscle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma |
| + |
CSRP3 | up-regulates activity
binding
|
MYOG |
0.535 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241113 |
|
|
Mus musculus |
C3H10T1/2 Cell |
| pmid |
sentence |
| 9234731 |
we found that nuclear MLP functions through a physical interaction with the muscle basic helix-loop-helix (bHLH) transcription factors MyoD, MRF4, and myogenin. we propose that it serves as a cofactor for the myogenic bHLH proteins by increasing their interaction with specific DNA regulatory elements. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HEY1 | down-regulates quantity by repression
transcriptional regulation
|
MYOG |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235822 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 19917614 |
Our results indicate instead that hey1 is recruited to the promoter regions of myogenin and mef2c, two genes whose induction is critical for myogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | NOTCH Signaling and Myogenesis |
| + |
NFATC2 | up-regulates quantity by expression
transcriptional regulation
|
MYOG |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235006 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18676376 |
provide a novel transcriptional paradigm for the first steps of myogenesis, where a calcineurin/NFATc3 pathway regulates myogenin induction in cooperation with MyoD during myogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
MYOG | down-regulates quantity by destabilization
|
PAX7 |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255638 |
|
|
Mus musculus |
C3H10T1/2 Cell |
| pmid |
sentence |
| 17548510 |
Indeed, we observed a reduction in Pax7 protein levels upon ectopic myogenin expression in MM14 myoblasts, even under proliferation conditions |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma |
| + |
MYOD1/SWI/SNF complex | up-regulates quantity by expression
transcriptional regulation
|
MYOG |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151688 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17194702 |
Myod targets brg1 to the myogenin promoter during the initiation of myogenesis in tissue culture models for skeletal muscle differentiation /initiation of myogenin transcription is dependent upon myod, the pbx homeodomain factor, and swi/snf chromatin-remodeling enzymes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
DACH2 | down-regulates quantity by repression
transcriptional regulation
|
MYOG |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261579 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 17075071 |
We confirmed Dach2 is a Mgn transcriptional repressor that mediates HDAC-dependent regulation by (i) overexpressing Dach2 in myotubes harboring the 133-bp Mgn promoter and (ii) rescuing TSA-mediated Mgn repression by Dach2 knockdown. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYOG | up-regulates quantity by expression
transcriptional regulation
|
MYF6 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255642 |
|
|
|
|
| pmid |
sentence |
| 7739551 |
[...] confirming that myogenin binds to the E1 and E2 E boxes located in close proximity to the MRF4 transcription start site. |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis |
| + |
ANGPT1 | up-regulates quantity by expression
transcriptional regulation
|
MYOG |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241554 |
|
|
Mus musculus |
Myoblast |
| pmid |
sentence |
| 26042050 |
Exogenous Ang-1 enhanced myogenic (MyoD and Myogenin) mRNA in differentiating myoblasts and increased myosin heavy chain protein. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYOG | up-regulates quantity by expression
transcriptional regulation
|
DES |
0.257 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241501 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 25653159 |
Ectopic expression of myogenin and a specific Mef2 isoform induced myogenic differentiation without activating endogenous MyoD expression. Under these conditions, the regulatory sequences of late gene loci were not in close proximity, and these genes were prematurely activated. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Myog/SWI/SNF complex | up-regulates quantity by expression
transcriptional regulation
|
MYOG |
0.633 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151697 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17194702 |
Upon the expression of myogenin, myogenin, mef2d, and brg1 localize to the myogenin promoter to maintain myogenin expression./ Swi/snf chromatin-remodeling activity is required for myogenin expression in differentiated skeletal muscle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
TEK | up-regulates quantity by expression
transcriptional regulation
|
MYOG |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241535 |
|
|
Mus musculus |
Myoblast |
| pmid |
sentence |
| 26042050 |
the effects of the angiopoietins are not specific for vascular endothelial cells, as their receptors (Tie1, Tie2) are known to be expressed in hematopoietic cells and they have also recently been shown to be expressed in skeletal muscle cellsExogenous Ang-1 enhanced myogenic (MyoD and Myogenin) mRNA in differentiating myoblasts and increased myosin heavy chain protein. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYOG | down-regulates activity
binding
|
FBXO32 |
0.527 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-237854 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 19631210 |
Myogenin had a MAFbx-recognition motif and interacted with MAFbx. MAFbx activated polyubiquitination of myogenin. The results of this study suggest that MAFbx functions as an F-box protein for ubiquitination of myogenin. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | IGF and Myogenesis |
| + |
TGFB1 | down-regulates
|
MYOG |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235728 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14739161 |
Tgf-beta was shown to inhibit myogenin and mef2d expression and myotube formation in c2c12. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYOG | up-regulates activity
|
Skeletal_muscle_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255644 |
|
|
|
|
| pmid |
sentence |
| 7532173 |
These results suggest that at least initially, the muscle-forming regions contained cells with myogenic potential, and that this potential is lost in the myogenin mutants as development proceeds. |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Rhabdomyosarcoma |
| + |
SIX1 | up-regulates quantity by expression
transcriptional regulation
|
MYOG |
0.454 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62104 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9826681 |
We have demonstrated by studies of transgenic mice the importance of the mef3 motif present in the myogeninpromoter for its activation and have characterized the mef3 binding activity as consisting of two skeletal-muscle specific members of the six family, six1 and six4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
CIITA | down-regulates
binding
|
MYOG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255111 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28163303 |
During early stages of myogenesis, CIITA binds directly to myogenin (MYOG) and inactivates it, preventing MYOG-mediated induction of myogenic genes that are required for muscle differentiation and function |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
MYOG | up-regulates quantity by expression
transcriptional regulation
|
ITGA7 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241521 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 8798472 |
Only myogenin and MyoD were able to efficiently trans-activate the alpha7 promoter-CAT construct (Fig. 7). Myogenin trans-activated the promoter by _2-fold whereas MyoD was able to trans-activate by nearly 4-fold, indicating that both of these factors may play a role in alpha7 gene expression during muscle development. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
MYOG
- 
- 