Summary

Name MEF2C
Full Name Myocyte-specific enhancer factor 2C
Synonyms MEF2C_HUMAN
Primary ID Q06413
Links - -
Type protein
Relations 56
Pathways NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis, Pericyte: Myogenic transcriptional cascade, Rett syndrome, Satellite: Calcium&myogenesis, Satellite: Myogenic transcriptional cascade, Satellite: miRNA network
Function Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation MEF2C 0.756
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MEF2C 0.68
Publications: 5 Organism: Homo Sapiens
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation MEF2C 0.369
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation MEF2C 0.338
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation MEF2C 0.412
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MEF2C 0.273
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MEF2C 0.731
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MEF2C 0.616
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png binding MEF2C 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MEF2C 0.316
Publications: 1 Organism: Mus Musculus
Pathways:NOTCH Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MEF2C 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MEF2C 0.348
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MEF2C 0.294
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png , binding MEF2C 0.288
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MEF2C 0.379
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH2 0.448
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates img/indirect-activation.png MEF2C 0.288
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/indirect-activation.png Neurogenesis 0.7
Publications: 1 Organism: In Vitro
Pathways:Rett syndrome
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CPT1B 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CTNNA3 0.244
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKL5 0.362
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ up-regulates img/direct-activation.png binding MEF2C 0.698
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MEF2C 0.409
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MEF2C 0.339
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MEF2C 0.671
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MEF2C 0.427
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MEF2C 0.307
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MEF2C 0.531
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation JUN 0.604
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MEF2C 0.342
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MEF2C 0.284
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MEF2C 0.345
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/indirect-activation.png MEF2C 0.482
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation α-Catenin 0.469
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MEF2C 0.358
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ up-regulates img/indirect-activation.png MEF2C 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png binding MEF2C 0.372
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MEF2C 0.289
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MEF2C 0.726
Publications: 2 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/indirect-activation.png MEF2C 0.437
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MECP2 0.358
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ up-regulates img/direct-activation.png binding MEF2C 0.551
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH10 0.354
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ down-regulates img/indirect_inhibition.png MEF2C 0.651
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MEF2C 0.682
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MEF2C 0.324
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding MYOD1 0.733
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYF6 0.546
Publications: 1 Organism: Mus Musculus
Pathways:IGF and Myogenesis
+ up-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH1 0.395
Publications: 1 Organism: Mus Musculus
Pathways:IGF and Myogenesis