4.0
Vitamin-D Metabolism
Pathway ID: SIGNOR-VDM
Description: Vitamin D can be either be obtained from nutrition or synthesised by our body in a reaction that requires Ultraviolet radiation. Ultraviolet radiation results in the conversion of 7-dehydrocholesterol to pre–vitamin D, which isomerizes to vitamin D in the skin. Vitamin D–binding protein transports vitamin D to the liver, where it undergoes 25-hydroxylation by CYP2R1. CYP27B1 further hydroxylates 25-hydroxyvitamin D, resulting in the formation of the active hormone 1,25-dihydroxyvitamin D.
Curated by: Livia Perfetto
Description: Vitamin D can be either be obtained from nutrition or synthesised by our body in a reaction that requires Ultraviolet radiation. Ultraviolet radiation results in the conversion of 7-dehydrocholesterol to pre–vitamin D, which isomerizes to vitamin D in the skin. Vitamin D–binding protein transports vitamin D to the liver, where it undergoes 25-hydroxylation by CYP2R1. CYP27B1 further hydroxylates 25-hydroxyvitamin D, resulting in the formation of the active hormone 1,25-dihydroxyvitamin D.
Curated by: Livia Perfetto
13 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| CYP2R1 | Q6VVX0 |
| Food intake | SIGNOR-PH152 |
| GC | P02774 |
| propan-2-ol | CHEBI:17824 |
| vitamin D | CHEBI:27300 |
| CYP24A1 | Q07973 |
| calciol | CHEBI:28940 |
| calcitetrol | CHEBI:47799 |
| cholesta-5,7-dien-3beta-ol | CHEBI:17759 |
| UVB radiation | SIGNOR-ST17 |
| calcidiol | CHEBI:17933 |
| calcitriol | CHEBI:17823 |
| CYP27B1 | O15528 |