| + |
UVB radiation | up-regulates 
|
IL1A |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252384 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9767234 |
UVB can stimulate the synthesis of IL-1, TNF-a and ET-1, and other cytokines by keratinocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UVB radiation | up-regulates
|
EDN1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252383 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9767234 |
UVB can stimulate the synthesis of IL-1, TNF-a and ET-1, and other cytokines by keratinocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UVB radiation | down-regulates quantity 
chemical modification
|
cholesta-5,7-dien-3beta-ol |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270563 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30080183 |
Ultraviolet radiation results in the conversion of 7-dehydrocholesterol to pre-vitamin D, which isomerizes to vitamin D in the skin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | Vitamin-D Metabolism |
| + |
UVB radiation | up-regulates
|
DDB1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275685 |
|
|
|
|
| pmid |
sentence |
| 24086042 |
GG-NER is initiated by the GG-NER specific factor XPC-RAD23B, in some cases with the help of UV-DDB (UV-damaged DNA-binding protein). |
|
| Publications: |
1 |
| + |
UVB radiation | up-regulates quantity 
chemical modification
|
calciol |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270562 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30080183 |
Ultraviolet radiation results in the conversion of 7-dehydrocholesterol to pre-vitamin D, which isomerizes to vitamin D in the skin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | Vitamin-D Metabolism |
| + |
UVB radiation | up-regulates
|
GCH1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252206 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9204951 |
UVB light induces GTP-CH.-1 to increase the de novo synthesis of 6-BH4 in association with a concomitant increase in PAH activities, thus providing more L-tyrosine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UVB radiation | up-regulates
|
PAH |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252207 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9204951 |
UVB light induces GTP-CH.-1 to increase the de novo synthesis of 6-BH4 in association with a concomitant increase in PAH activities, thus providing more L-tyrosine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UVB radiation | up-regulates
|
MC1R |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252388 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9767234 |
Melanocyte-stimulating hormone (MSH) receptor binding activity and melanocortin-1 receptor (MC1-R) gene expression on normal human melanocytes have been studied as responses to the effects of ultraviolet B (UVB), interleukin-1 (IL-1), endothelin-1 (ET-1) and tumour necrosis factor-alpha (TNF-alpha), which are known as UV sensitive regulators of melanocytic function. MSH receptor (MSH-R) binding activity was upregulated by UVB, IL-1alpha, -1beta and ET-1, but was downregulated by TNF-alpha.Northern blotanalysis showed that MC1-R mRNA expression was induced 24 h after UVB irradiation in a dose-dependent manner, and that 24-h treatment with ET-1 also induced an expression of MC1-R mRNA,whereas TNF-a downregulated the expression. In addition, IL-1a and -1b have a small but real inductiveeffect on MC1-R mRNA expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UVB radiation | up-regulates
|
TNF |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252208 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19005488 |
UVB and proinflammatory cytokines synergistically activate TNF-alpha production in keratinocytes through enhanced gene transcription. UVB and IL-1alpha treatment synergistically enhanced TNF-alpha secretion and mRNA levels in human keratinocytes, similar to the findings reported previously in human fibroblasts. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UVB radiation | up-regulates
|
IL1B |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252382 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9767234 |
UVB can stimulate the synthesis of IL-1, TNF-a and ET-1, and other cytokines by keratinocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
UVB radiation