| + |
HMGCL | up-regulates quantity 
chemical modification
|
acetoacetic acid |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282489 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8617516 |
3-hydroxy-3-methylglutaryl CoA lyase (HL, EC 4.1.3.4) catalyzes the cleavage of 3-hydroxy-3-methylglutaryl CoA to acetoacetic acid and acetyl CoA, the final reaction of both ketogenesis and leucine catabolism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(3S)-3-hydroxy-3-methylglutaryl-CoA | up-regulates quantity
precursor of
|
acetoacetic acid |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282491 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8617516 |
3-hydroxy-3-methylglutaryl CoA lyase (HL, EC 4.1.3.4) catalyzes the cleavage of 3-hydroxy-3-methylglutaryl CoA to acetoacetic acid and acetyl CoA, the final reaction of both ketogenesis and leucine catabolism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BDH1 | down-regulates quantity 
chemical modification
|
acetoacetic acid |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282493 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40562122 |
β-Hydroxybutyrate dehydrogenase 1 (BDH1), a short-chain dehydrogenase located in the inner mitochondrial membrane, has been extensively studied for its critical role in ketone body metabolism. BDH1 catalyzes the interconversion between beta-hydroxybutyric acid (β-HB) and acetoacetic acid (AcAc) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
acetoacetic acid | up-regulates activity
precursor of
|
(R)-3-hydroxybutyric acid |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282497 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40562122 |
β-Hydroxybutyrate dehydrogenase 1 (BDH1), a short-chain dehydrogenase located in the inner mitochondrial membrane, has been extensively studied for its critical role in ketone body metabolism. BDH1 catalyzes the interconversion between beta-hydroxybutyric acid (β-HB) and acetoacetic acid (AcAc) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BDH1 | up-regulates quantity
chemical modification
|
acetoacetic acid |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282499 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40562122 |
β-Hydroxybutyrate dehydrogenase 1 (BDH1), a short-chain dehydrogenase located in the inner mitochondrial membrane, has been extensively studied for its critical role in ketone body metabolism. BDH1 catalyzes the interconversion between beta-hydroxybutyric acid (β-HB) and acetoacetic acid (AcAc) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(R)-3-hydroxybutyric acid | up-regulates activity
precursor of
|
acetoacetic acid |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282503 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40562122 |
β-Hydroxybutyrate dehydrogenase 1 (BDH1), a short-chain dehydrogenase located in the inner mitochondrial membrane, has been extensively studied for its critical role in ketone body metabolism. BDH1 catalyzes the interconversion between beta-hydroxybutyric acid (β-HB) and acetoacetic acid (AcAc) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OXCT1 | down-regulates quantity
chemical modification
|
acetoacetic acid |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282504 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10964512 |
Succinyl-CoA:3-ketoacid-CoA transferase (SCOT2 ; EC 2.8.3.5), a mitochondrial homodimer essential for ketone body utilization, catalyzes the activation of acetoacetate to acetoacetyl-CoA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
acetoacetic acid | up-regulates quantity
precursor of
|
acetoacetyl-CoA(4-) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282509 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10964512 |
Succinyl-CoA:3-ketoacid-CoA transferase (SCOT2 ; EC 2.8.3.5), a mitochondrial homodimer essential for ketone body utilization, catalyzes the activation of acetoacetate to acetoacetyl-CoA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OXCT2 | down-regulates quantity
chemical modification
|
acetoacetic acid |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282510 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10964512 |
Succinyl-CoA:3-ketoacid-CoA transferase (SCOT2 ; EC 2.8.3.5), a mitochondrial homodimer essential for ketone body utilization, catalyzes the activation of acetoacetate to acetoacetyl-CoA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
acetoacetic acid