| + |
5'-S-methyl-5'-thioadenosine | up-regulates quantity 
precursor of
|
adenine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278891 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3091600 |
The reaction catalyzed by the enzyme is fully reversible with a Keq of 1.39 X 10(-2) (in the direction of phosphorolysis) at 37 degrees C and pH 7.4. The Km values for 5'-methylthioadenosine, phosphate, adenine, and 5-methylthioribose 1-phosphate are 5, 320, 23, and 8 microM, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APRT | down-regulates quantity 
chemical modification
|
adenine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280464 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15196008 |
In mammals, adenine phosphoribosyltransferase (APRT, EC 2.4.2.7) is present in all tissues and provides the only known mechanism for the metabolic salvage of adenine resulting from the polyamine biosynthesis pathway or from dietary sources. Phosphoribosyltransferases (PRTases) catalyze the displacement of a PRPP α-1‘-pyrophosphate through a nitrogen-containing nucleophile. The reaction products are a β-1-substituted ribose 5‘-phosphate and a free pyrophosphate (PP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
adenine | up-regulates quantity
precursor of
|
AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280468 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15196008 |
In mammals, adenine phosphoribosyltransferase (APRT, EC 2.4.2.7) is present in all tissues and provides the only known mechanism for the metabolic salvage of adenine resulting from the polyamine biosynthesis pathway or from dietary sources. Phosphoribosyltransferases (PRTases) catalyze the displacement of a PRPP α-1‘-pyrophosphate through a nitrogen-containing nucleophile. The reaction products are a β-1-substituted ribose 5‘-phosphate and a free pyrophosphate (PP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTAP | up-regulates quantity
chemical modification
|
adenine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278890 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3091600 |
The reaction catalyzed by the enzyme is fully reversible with a Keq of 1.39 X 10(-2) (in the direction of phosphorolysis) at 37 degrees C and pH 7.4. The Km values for 5'-methylthioadenosine, phosphate, adenine, and 5-methylthioribose 1-phosphate are 5, 320, 23, and 8 microM, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
adenine