+ |
Daunorubicin hydrochloride | down-regulates activity
chemical inhibition
|
TOP2B |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259323 |
|
|
Homo sapiens |
|
pmid |
sentence |
1963303 |
DNA topoisomerase II as the primary target of anti-tumor anthracyclines.Such studies have also given evidence of the peculiar features of the drug interference with DNA topoisomerase II activity. In contrast to other cytotoxic topoisomerase II inhibitors (acridines, epipodophyllotoxins), anthracyclines produce persistent DNA cleavable complexes. This property is more evident with doxorubicin derivatives than with daunorubicin derivatives. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
Daunorubicin hydrochloride | down-regulates activity
chemical inhibition
|
TOP2A |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259322 |
|
|
Homo sapiens |
|
pmid |
sentence |
1963303 |
DNA topoisomerase II as the primary target of anti-tumor anthracyclines.Such studies have also given evidence of the peculiar features of the drug interference with DNA topoisomerase II activity. In contrast to other cytotoxic topoisomerase II inhibitors (acridines, epipodophyllotoxins), anthracyclines produce persistent DNA cleavable complexes. This property is more evident with doxorubicin derivatives than with daunorubicin derivatives. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |