| + |
CSNK1D | down-regulates quantity by destabilization 
phosphorylation
|
TOP2B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277509 |
Ser1132 |
QNQHDDSsSDSGTPS |
Homo sapiens |
|
| pmid |
sentence |
| 32015321 |
Specifically, DNA damage signal, triggered by teniposide (VM-26) treatment, activates ATM, cooperating with CK1 to phosphorylate TOP2β on Ser1134 and Ser1130, respectively, in a canonical degron motif to facilitate β-TrCP binding and subsequent degradation.CK1 binds with and phosphorylates TOP2β at Ser1130 to promote its degradation by VM-26. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATM | down-regulates quantity by destabilization
phosphorylation
|
TOP2B |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277510 |
Ser1135 |
HDDSSSDsGTPSGPD |
Homo sapiens |
|
| pmid |
sentence |
| 32015321 |
Specifically, DNA damage signal, triggered by teniposide (VM-26) treatment, activates ATM, cooperating with CK1 to phosphorylate TOP2β on Ser1134 and Ser1130, respectively, in a canonical degron motif to facilitate β-TrCP binding and subsequent degradation.ATM binds with and phosphorylates TOP2β at Ser1134 to promote its degradation by VM-26. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
valrubicin | down-regulates activity
chemical inhibition
|
TOP2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259384 |
|
|
Homo sapiens |
Urinary Bladder Cell Line |
| pmid |
sentence |
| 16019763 |
Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a semi-synthetic derivative of the anthracycline doxorubicin. Valrubicin inhibits the incorporation of nucleosides into nucleic acids, causing extensive chromosomal damage and cell-cycle arrest in the G2 phase. Its principal metabolites inhibit topoisomerase II, thus arresting DNA synthesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Daunorubicin hydrochloride | down-regulates activity
chemical inhibition
|
TOP2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259323 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1963303 |
DNA topoisomerase II as the primary target of anti-tumor anthracyclines.Such studies have also given evidence of the peculiar features of the drug interference with DNA topoisomerase II activity. In contrast to other cytotoxic topoisomerase II inhibitors (acridines, epipodophyllotoxins), anthracyclines produce persistent DNA cleavable complexes. This property is more evident with doxorubicin derivatives than with daunorubicin derivatives. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TOP2B | up-regulates quantity by expression 
transcriptional regulation
|
SST |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242305 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24463367 |
While Top2a is essential in proliferating cells and has been linked to DNA replication and chromosome condensation/segregation, Top2b has been clearly indicated in regulating gene expression (e.g. Reln, Dab1, Catna2, Cdh13, Sst, Pbx3, and Epha7) during brain development |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TOP2B | up-regulates quantity by expression
transcriptional regulation
|
CDH13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242302 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24463367 |
While Top2a is essential in proliferating cells and has been linked to DNA replication and chromosome condensation/segregation, Top2b has been clearly indicated in regulating gene expression (e.g. Reln, Dab1, Catna2, Cdh13, Sst, Pbx3, and Epha7) during brain development |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TOP2B | down-regulates 
|
Survival |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242533 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24463367 |
Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
teniposide | down-regulates activity
chemical inhibition
|
TOP2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259330 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1329225 |
Recognition of transient DNA breaks induced by teniposide, etoposide, and other podophyllotoxin analogues established not only that their site of activity was DNA but also that their cytotoxic effect was dose-dependent. Extensive investigation has further indicated that a primary mechanism of action of these agents involves inhibition of the catalytic activity of eukaryote topoisomerase II and, more important, the consequent stabilization of the normally transient covalent intermediate formed between the DNA substrate and the enzyme. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TOP2B | up-regulates quantity by expression
transcriptional regulation
|
DAB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242210 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24463367 |
While Top2a is essential in proliferating cells and has been linked to DNA replication and chromosome condensation/segregation, Top2b has been clearly indicated in regulating gene expression (e.g. Reln, Dab1, Catna2, Cdh13, Sst, Pbx3, and Epha7) during brain development |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TOP2B | up-regulates quantity by expression
transcriptional regulation
|
PBX3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242308 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24463367 |
While Top2a is essential in proliferating cells and has been linked to DNA replication and chromosome condensation/segregation, Top2b has been clearly indicated in regulating gene expression (e.g. Reln, Dab1, Catna2, Cdh13, Sst, Pbx3, and Epha7) during brain development |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
etoposide | down-regulates activity
chemical inhibition
|
TOP2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259326 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16101488 |
Etoposide is an important chemotherapeutic agent that is used to treat a wide spectrum of human cancers. It has been in clinical use for more than two decades and remains one of the most highly prescribed anticancer drugs in the world. The primary cytotoxic target for etoposide is topoisomerase II. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TOP2B | up-regulates quantity by expression
transcriptional regulation
|
RELN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242207 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24463367 |
While Top2a is essential in proliferating cells and has been linked to DNA replication and chromosome condensation/segregation, Top2b has been clearly indicated in regulating gene expression (e.g. Reln, Dab1, Catna2, Cdh13, Sst, Pbx3, and Epha7) during brain development |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TOP2B | up-regulates quantity by expression
transcriptional regulation
|
EPHA7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242311 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24463367 |
While Top2a is essential in proliferating cells and has been linked to DNA replication and chromosome condensation/segregation, Top2b has been clearly indicated in regulating gene expression (e.g. Reln, Dab1, Catna2, Cdh13, Sst, Pbx3, and Epha7) during brain development |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCF-betaTRCP | down-regulates quantity by destabilization
polyubiquitination
|
TOP2B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277511 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32015321 |
Specifically, DNA damage signal, triggered by teniposide (VM-26) treatment, activates ATM, cooperating with CK1 to phosphorylate TOP2β on Ser1134 and Ser1130, respectively, in a canonical degron motif to facilitate β-TrCP binding and subsequent degradation.ATM binds with and phosphorylates TOP2β at Ser1134 to promote its degradation by VM-26. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
idarubicin | down-regulates activity
chemical inhibition
|
TOP2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259328 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20824055 |
Topoisomerase II (Top2) is a nuclear enzyme involved in several metabolic processes of DNA. Chemotherapy agents that poison Top2 are known to induce persistent protein-mediated DNA double strand breaks (DSB). In this report, by using knock down experiments, we demonstrated that Top2α was largely responsible for the induction of γH2AX and cytotoxicity by the Top2 poisons idarubicin and etoposide in normal human cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TOP2B
- 
- 