| + |
Cyclopamine | down-regulates 
chemical inhibition
|
SMO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174432 |
|
|
Homo sapiens |
Medulloblastoma Cell |
| pmid |
sentence |
| 12202832 |
We investigate the therapeutic efficacy of the Hh pathway antagonist cyclopamine in preclinical models of medulloblastoma, the most common malignant brain tumor in children. Cyclopamine treatment of murine medulloblastoma cells blocked proliferation in vitro and induced changes in gene expression consistent with initiation of neuronal differentiation and loss of neuronal stem cell-like character. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191227 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95270 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 12414725 |
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to vertebrate Hedgehog signaling. We show here, using photoaffinity and fluorescent derivatives, that this inhibitory effect is mediated by direct binding of cyclopamine to the heptahelical bundle of Smoothened (Smo) |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| Pathways: | Sonic Hedgehog |
| + |
Cyclopamine | down-regulates
chemical inhibition
|
CXCL1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148469 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Cyclopamine and other inhibitors of hh signaling were found to inhibit smo coupling to gi in a manner consistent with inverse agonism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Cyclopamine
