| + |
IMP | up-regulates quantity 
precursor of
|
5'-xanthylic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267330 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19480389 |
IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. Humans and other mammals have two IMPDH genes, encoding hIMPDH1 and hIMPDH2. The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine nucleotide biosynthesis. XMP is subsequently converted to GMP by the action of GMP synthetase (GMPS). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267333 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19480389 |
IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine nucleotide biosynthesis. XMP is subsequently converted to GMP by the action of GMP synthetase (GMPS). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
5'-xanthylic acid | up-regulates quantity
precursor of
|
L-glutamate(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268095 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 6698284 |
The de novo synthesis of guanosine monophosphate (GMP) involves the oxidation of inosine monophosphate (IMP) to xanthosine monophosphate (XMP) followed by amination to GMP. This latter reaction is catalyzed by GMP synthetase. (XMP: I.-glutamine amidoligase (AMP) EC 6.3.5.2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
GMPS | down-regulates quantity 
chemical modification
|
5'-xanthylic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267337 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 6698284 |
The de novo synthesis of guanosine monophosphate (GMP) involves the oxidation of inosine monophosphate (IMP) to xanthosine monophosphate (XMP) followed by amination to GMP. This latter reaction is catalyzed by GMP synthetase. (XMP: I.-glutamine amidoligase (AMP) EC 6.3.5.2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
IMPDH2 | up-regulates quantity
chemical modification
|
5'-xanthylic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267335 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19480389 |
IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine nucleotide biosynthesis. XMP is subsequently converted to GMP by the action of GMP synthetase (GMPS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
IMPDH1 | up-regulates quantity
chemical modification
|
5'-xanthylic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267332 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19480389 |
IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine nucleotide biosynthesis. XMP is subsequently converted to GMP by the action of GMP synthetase (GMPS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
5'-xanthylic acid | up-regulates quantity
precursor of
|
guanosine 5'-monophosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267336 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 6698284 |
The de novo synthesis of guanosine monophosphate (GMP) involves the oxidation of inosine monophosphate (IMP) to xanthosine monophosphate (XMP) followed by amination to GMP. This latter reaction is catalyzed by GMP synthetase. (XMP: I.-glutamine amidoligase (AMP) EC 6.3.5.2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
3.0
5'-xanthylic acid