Summary

Name IMPDH1
Full Name Inosine-5'-monophosphate dehydrogenase 1
Synonyms IMP dehydrogenase 1, IMPD 1, IMPDH 1, IMPDH-I | IMPD1
Primary ID P20839
Links - -
Type protein
Relations 3
Pathways Nucleotide Biosynthesis
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png chemical modification 5'-xanthylic acid 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ down-regulates quantity img/direct_inhibition.png chemical modification IMP 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IMPDH1 0.246
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis