| + |
1-phosphatidyl-1D-myo-inositol 3-phosphate | form complex 
binding
|
Early Endosome |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260622 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19924646 |
PtdIns(3)P-kinase/hVPS34/p150 (VPS34) is thought to be one of the first Rab5 effector proteins to be recruited to the EE . As suggested by its name, its primary role is to generate PtdIns(3)P, which is the most abundant phosphoinositide in the EE membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAS complex | down-regulates quantity 
chemical modification
|
1-phosphatidyl-1D-myo-inositol 3-phosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253533 |
|
|
in vitro |
|
| pmid |
sentence |
| 18950639 |
PtdIns(3,5)P2 is synthesized from PtdIns(3)P through the action of mammalian PIKfyve or the yeast counterpart Fab1, both sole enzymes for PtdIns(3,5)P2 synthesis. PIKfyve and Fab1, in turn, are activated by the orthologous proteins, mammalian ArPIKfyve and yeast Vac14, to upregulate intracellular PtdIns(3,5)P2 production. PtdIns(3,5)P2 turnover is catalyzed, at least in part, by mammalian Sac3 or its yeast counterpart Fig4 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PIK3C3 | up-regulates 
chemical modification
|
1-phosphatidyl-1D-myo-inositol 3-phosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45606 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8999962 |
Vps34p phosphorylates phosphatidylinositol (ptdins) at the 3?-Position of the inositol ring, but not ptdins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
1-phosphatidyl-1D-myo-inositol 3-phosphate