Summary

Name PIK3C3
Full Name Phosphatidylinositol 3-kinase catalytic subunit type 3
Synonyms PI3-kinase type 3, PI3K type 3, PtdIns-3-kinase type 3, Phosphatidylinositol 3-kinase p100 subunit, Phosphoinositide-3-kinase class 3, hVps34 | VPS34
Primary ID Q8NEB9
Links - -
Type protein
Relations 24
Pathways Autophagy
Inhibitors 3-methyladenine; wortmannin; LY294002
Function Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation PIK3C3 0.369
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PIK3C3 0.435
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PIK3C3 0.369
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Vps34 Complex I 0.917
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ up-regulates img/direct-activation.png chemical modification 1-phosphatidyl-1D-myo-inositol 3-phosphate 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BECN1 0.934
Publications: 1 Organism: Mus Musculus
Pathways:Autophagy
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3C3 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PIK3C3 0.285
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3C3 0.8
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/indirect-activation.png AKT 0.451
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3C3 0.938
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3C3 0.804
Publications: 1 Organism: Homo Sapiens
Pathways:Autophagy
+ up-regulates img/indirect-activation.png AKT1 0.451
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PTEN 0.65
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PIK3C3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding PIK3C3 0.301
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Vps34 Complex II 0.892
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ up-regulates activity img/direct-activation.png binding PIK3C3 0.878
Publications: 1 Organism: Mus Musculus
Pathways:Autophagy
+ down-regulates activity img/direct_inhibition.png binding PIK3C3 0.675
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization AKT1 0.451
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3C3 0.938
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3C3 0.8
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png relocalization AKT 0.451
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor PIK3C3 0.506
Publications: 1