| + |
serotonin | up-regulates activity 
chemical activation
|
HTR3B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264290 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR3D |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264292 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAOA | down-regulates quantity 
chemical modification
|
serotonin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264014 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31024440 |
Following release, 5-HT receptor activation and reuptake by 5-HT transporter (5-HTT), serotonin is degraded by MAO (monoamine oxidase) and ALDH (aldehyde dehydrogenase) into 5-hydroxyindole-3-acetic acid (5-HIAA). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Catecholamine metabolism |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR1A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264285 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258846 |
|
|
Cricetulus griseus |
|
| pmid |
sentence |
| 9760039 |
A range of serotonergic agonists and partial agonists were tested for their capacity to stimulate 5-HT1A receptor mediated GTPg binding in CHO-h5-HT1A membranes. The methoxynaphtylpiperazine ligand, S 14671,was the most potent agonist tested, with virtually full agonist activity, relative to 5-HT Table 1; Fig. 2C consistent with its exceptionally potent and efficacious actions in in vivo functional paradigms. Its analogue, S 14506 was also a highly potent and efficacious ligand (Emax90%) in agreement with previous in vivo studies ( Schreiber et al., 1994 ). (+)UH 301 exhibited partial agonist activity at 5-HT1A receptors |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258889 |
|
|
Cricetulus griseus |
|
| pmid |
sentence |
| 9550290 |
Together, these data show that (i) [3H]-S 15535 is a highly selective 5-HT1A receptor ligand which labels both G-protein-coupled and uncoupled 5-HT1A receptors, (ii) antagonists, such as WAY 100,635, which yield monophasic isotherms in competition with both [3H]-agonists and [3H]-antagonists, are not sensitive to the G-protein coupling state of the receptor, but (iii) spiperone and methiothepin behaved as inverse agonists, their competition isotherms with [3H]-S 15535 being modulated in an opposite manner to those of agonists. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Cricetulus Griseus |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR7 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264289 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR2C |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264283 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BLOC-1 | up-regulates quantity
relocalization
|
serotonin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265999 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23805129 |
The multidrug transporter MRP4, a multidrug resistance protein, is found on platelet dense granules and is proposed to transport adenine nucleotides into these granules (Jedlitschky et al., 2004). Uptake of serotonin from platelet cytosol into dense granules is mediated by vesicular monoamine transporter 2 (VMAT2). |VMAT2 also appears to mediate histamine transport into dense granules |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR3E |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264291 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR3A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264282 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates quantity
precursor of
|
3,4-dihydroxyphenylacetaldehyde |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264187 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31024440 |
Following release, 5-HT receptor activation and reuptake by 5-HT transporter (5-HTT), serotonin is degraded by MAO (monoamine oxidase) and ALDH (aldehyde dehydrogenase) into 5-hydroxyindole-3-acetic acid (5-HIAA). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264188 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31024440 |
Following release, 5-HT receptor activation and reuptake by 5-HT transporter (5-HTT), serotonin is degraded by MAO (monoamine oxidase) and ALDH (aldehyde dehydrogenase) into 5-hydroxyindole-3-acetic acid (5-HIAA). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Catecholamine metabolism |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR1E |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264288 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR1F |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264297 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC6A4 | up-regulates quantity
relocalization
|
serotonin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263953 |
|
|
Homo sapiens |
Central Nervous System |
| pmid |
sentence |
| 16789923 |
The function of the serotonin transporter (SERT) is to take up and release serotonin (5-hydroxytyptamine (5-HT)) from cells and this function of SERT in the central nervous system (CNS) is well-documented; SERT is the target of selective serotonin reuptake inhibitors used in the treatment of CNS disorders, such as depression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263952 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 17506858 |
Serotonin (5HT) is a platelet-stored vasoconstrictor. Altered concentrations of circulating 5HT are implicated in several pathologic conditions, including hypertension. The actions of 5HT are mediated by different types of receptors and terminated by a single 5HT transporter (SERT). Therefore, SERT is a major mechanism that regulates plasma 5HT levels to prevent vasoconstriction and thereby secure a stable blood flow. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR6 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264295 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates activity
chemical activation
|
AANAT |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265477 |
|
|
in vitro |
|
| pmid |
sentence |
| 22775292 |
Here, we present the X-ray crystal structure of human N-acetyl serotonin methyltransferase (ASMT), the last enzyme of the melatonin biosynthesis pathway. Melatonin synthesis requires serotonin, which is first acetylated by the arylalkylamine N-acetyltransferase (AA-NAT) to produce N-acetyl serotonin (NAS) (Fig. 1A). Then, acetyl serotonin methyltransferase (ASMT, also known as hydroxyindole O-methyltransferase or HIOMT) produces melatonin by transferring a methyl group from the cofactor S-adenosyl-L-methionine (SAM) to NAS. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264294 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAOB | down-regulates quantity
chemical modification
|
serotonin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264015 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31024440 |
Following release, 5-HT receptor activation and reuptake by 5-HT transporter (5-HTT), serotonin is degraded by MAO (monoamine oxidase) and ALDH (aldehyde dehydrogenase) into 5-hydroxyindole-3-acetic acid (5-HIAA). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR3C |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264296 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR1D |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264287 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DDC | up-regulates quantity
chemical modification
|
serotonin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263987 |
|
|
Danio rerio |
|
| pmid |
sentence |
| 23940784 |
AADC is responsible for the decarboxylation step in the catecholamine and dopamine biosynthesis. Dopamine and serotonin can be synthesized by AADC from L-3,4-dihydroxyphenylalanine and 5-hydroxytryptophan, respectively [7]. A deficiency in AADC will lead to reduced biogenic monoamines, including dopamine, norepinephrine, epinephrine, and serotonin |
|
| Publications: |
1 |
Organism: |
Danio Rerio |
| Pathways: | Catecholamine metabolism |
| + |
5-hydroxy-L-tryptophan | up-regulates quantity
precursor of
|
serotonin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264186 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31024440 |
In serotonergic neurons Trp serves as the precursor for 5-HT. The 5-HT metabolic pathway is initiated by Trp being hydroxylated to the intermediate 5-hydroxytryptophan (5-HTP), which is subsequently decarboxylated to become 5-HT |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Catecholamine metabolism |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR1B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264284 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR2A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264293 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR5A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264298 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
serotonin | up-regulates activity
chemical activation
|
HTR2B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264286 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25601315 |
Serotonin or 5-hydroxytryptamine (5-HT) remains one of the most widely studied chemical messengers. Serotonin produces a myriad of physiological effects in humans, mediated through 14 distinct receptor subtypes, of which 13 are G protein coupled receptors (GPCRs), and one ligand-gated cation channel |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
serotonin