| + |
FYN | up-regulates activity 
phosphorylation
|
KCND3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276396 |
Tyr108 |
GKLHYPRyECISAYD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22198508 |
These results indicate that Y108 (for Src-family kinases) and Y136 (for EGFR kinase) are involved in the tyrosine phosphorylation of hKv4.3 channels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC_kinase_family | up-regulates activity
phosphorylation
|
KCND3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275566 |
Tyr108 |
GKLHYPRyECISAYD |
|
|
| pmid |
sentence |
| 22198508 |
Our results demonstrate that human atrial I(to) and cloned hKv4.3 channels are modulated by EGFR kinase via phosphorylation of the Y136 residue and by Src-family kinases via phosphorylation of the Y108 residue|We found that human atrial I(to) was inhibited by the broad-spectrum PTK inhibitor genistein, the selective epidermal growth factor receptor (EGFR) kinase inhibitor AG556, and the Src-family kinases inhibitor PP2. |
|
| Publications: |
1 |
| + |
SRC | up-regulates activity
phosphorylation
|
KCND3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276393 |
Tyr108 |
GKLHYPRyECISAYD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22198508 |
These results indicate that Y108 (for Src-family kinases) and Y136 (for EGFR kinase) are involved in the tyrosine phosphorylation of hKv4.3 channels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGR | up-regulates activity
phosphorylation
|
KCND3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276394 |
Tyr108 |
GKLHYPRyECISAYD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22198508 |
These results indicate that Y108 (for Src-family kinases) and Y136 (for EGFR kinase) are involved in the tyrosine phosphorylation of hKv4.3 channels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LYN | up-regulates activity
phosphorylation
|
KCND3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276395 |
Tyr108 |
GKLHYPRyECISAYD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22198508 |
These results indicate that Y108 (for Src-family kinases) and Y136 (for EGFR kinase) are involved in the tyrosine phosphorylation of hKv4.3 channels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGFR | up-regulates activity
phosphorylation
|
KCND3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275549 |
Tyr136 |
GDCCYEEyKDRKREN |
|
|
| pmid |
sentence |
| 22198508 |
Our results demonstrate that human atrial I(to) and cloned hKv4.3 channels are modulated by EGFR kinase via phosphorylation of the Y136 residue and by Src-family kinases via phosphorylation of the Y108 residue|We found that human atrial I(to) was inhibited by the broad-spectrum PTK inhibitor genistein, the selective epidermal growth factor receptor (EGFR) kinase inhibitor AG556, and the Src-family kinases inhibitor PP2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276397 |
Tyr136 |
GDCCYEEyKDRKREN |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22198508 |
These results indicate that Y108 (for Src-family kinases) and Y136 (for EGFR kinase) are involved in the tyrosine phosphorylation of hKv4.3 channels. |
|
| Publications: |
2 |
Organism: |
, Homo Sapiens |
| + |
KCND3 | down-regulates quantity 
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265657 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24762397 |
Kv4.3 belongs to voltage activated (Kv) K+ channel, mammalian Shal-related family. It is encoded by KCND3 gene and expressed in heart, brain and smooth muscle. Transient outward K+ current (I(to)) plays a crucial role in the early phase of cardiac action potential repolarization. Kv4.3 K(+) channel is an important component of I(to). The function and expression of Kv4.3 K(+) channel decrease in variety of heart diseases, especially in heart hypertrophy/heart failure. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
KCND3
- 
- 