Summary

Name ARNTL
Full Name Aryl hydrocarbon receptor nuclear translocator-like protein 1
Synonyms Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, Class E basic helix-loop-helix protein 5, bHLHe5, Member of PAS protein 3, PAS domain-containing protein 3, bHLH-PAS protein JAP3 | BHLHE5, BMAL1, MOP3, PASD3
Primary ID O00327
Links - -
Type protein
Relations 25
Pathways Circadian clock
Function Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation ARNTL 0.391
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.407
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.515
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.49
Publications: 2 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.681
Publications: 2 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER2 0.738
Publications: 1
Pathways:Circadian clock
+ form complex img/form-complex.png binding CLOCK/BMAL1 0.771
Publications: 1 Organism: In Vitro
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPARA 0.583
Publications: 1 Organism: Mus Musculus
Tissue: Liver
Pathways:Circadian clock
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ARNTL 0.663
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation ARNTL 0.48
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation ARNTL 0.663
Publications: 2 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CRY1 0.932
Publications: 1
Pathways:Circadian clock
+ down-regulates activity img/direct_inhibition.png binding MAGEL2 0.377
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.583
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation ARNTL 0.349
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ARNTL 0.322
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER1 0.724
Publications: 1
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.504
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CRY2 0.932
Publications: 1
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER3 0.584
Publications: 1
Pathways:Circadian clock
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation VWF 0.33
Publications: 1 Organism: Mus Musculus