Summary
Name | TOP1 View Modifications |
Full Name | DNA topoisomerase 1 |
Synonyms | DNA topoisomerase I |
Primary ID | P11387 |
Links | - - |
Type | protein |
Relations | 9 |
Inhibitors | topotecan; irinotecan |
Function | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter. |
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Modifications Tables
Relations
Regulator | Mechanism | target | score ℹ | |
---|---|---|---|---|
+ | CSNK2A1 | up-regulates activity phosphorylation | TOP1 | 0.392 |
Publications: | 1 | Organism: | In Vitro | |
+ | CDK1 | up-regulates activity phosphorylation | TOP1 | 0.362 |
Publications: | 2 | Organism: | In Vitro | |
+ | PRKCA | up-regulates activity phosphorylation | TOP1 | 0.2 |
Publications: | 1 | Organism: | In Vitro | |
+ | ABL1 | up-regulates activity phosphorylation | TOP1 | 0.41 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | NONO | up-regulates binding | TOP1 | 0.384 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | topotecan | down-regulates activity chemical inhibition | TOP1 | 0.8 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | SFPQ | up-regulates binding | TOP1 | 0.38 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | irinotecan | down-regulates activity chemical inhibition | TOP1 | 0.8 |
Publications: | 1 | Organism: | Homo Sapiens | |