Relation Results

Summary

Name AGRN
Full Name Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment
Synonyms AGRIN_HUMAN | AGRIN
Primary ID O00468
Links - -
Type protein
Relations 3
Function [Isoform 1]

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Type: Score: Layout: SPV 
0.20.2730.848AGRNCHRNB3FUSLRP4

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Relations
Regulator
Mechanism
target
score ℹ
+ AGRNup-regulates activity img/direct-activation.png binding CHRNB3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264260 Homo sapiens Striated Muscle Cell
pmid sentence
Treatment of muscle cells with neural agrin causes tyrosine phosphorylation of the AChR β subunit and induces AChR clustering by promoting anchoring of the receptor protein to postsynaptic cytoskeleton. Regulation of acetylcholine receptor clustering by the tumor suppressor APC. By showing a direct requirement for APC in AChR clustering, our present study suggests that the Wnt/β-catenin pathway may crosstalk with the agrin signaling cascade during the formation of mammalian neuromuscular junction.
Publications: 1 Organism: Homo Sapiens
+ FUSdown-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation AGRN 0.273
Identifier Residue Sequence Organism Cell Line
SIGNOR-262807 Mus musculus
pmid sentence
This conclusion is also supported by the analysis of alternative splicing events in hFUS+/+; Smn+/− mice. As shown in Fig. 6b, the splicing of Dusp22, Mphosph9, Adarb1, hnRNP A2/B1, Gria4, Vps16, Atxn2 and Agrin, which are significantly affected in hFUS+/+ mice, is not further modified by SMN decrease
Publications: 1 Organism: Mus Musculus
+ AGRNup-regulates activity img/direct-activation.png binding LRP4 0.848
Identifier Residue Sequence Organism Cell Line
SIGNOR-273849 Homo sapiens
pmid sentence
AGRN is released by the nerve and binds to LRP4, which then binds to MuSK. This interaction leads to MuSK autophosphorylation and activation of its kinase function, leading to anterograde signalling by subsequent phosphorylation of DOK7 (not shown), which binds MuSK as a dimer.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
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