| + |
AGRN | up-regulates activity 
binding
|
CHRNB3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264260 |
|
|
Homo sapiens |
Striated Muscle Cell |
| pmid |
sentence |
| 14502292 |
Treatment of muscle cells with neural agrin causes tyrosine phosphorylation of the AChR β subunit and induces AChR clustering by promoting anchoring of the receptor protein to postsynaptic cytoskeleton. Regulation of acetylcholine receptor clustering by the tumor suppressor APC. By showing a direct requirement for APC in AChR clustering, our present study suggests that the Wnt/β-catenin pathway may crosstalk with the agrin signaling cascade during the formation of mammalian neuromuscular junction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHRNB3 | form complex 
binding
|
Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280911 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 25460185 |
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of pentameric ligand-gated cation channels that are expressed throughout the brain and involved in a wide range of physiological and pathophysiological processes. The nAChR subtypes share a common basic structure, but their biophysical and pharmacological properties depend on their subunit composition, which is therefore central to understanding their function in the nervous system and discovering new subtype selective drugs.The variety of subtypes in the mammalian nervous system, is mainly due to the diversity of the possible combinations of the eleven neuronal subunits (all but α8) expressed in this animal class. nAChR subtypes can be divided into two main classes: 1) αBgtx-sensitive subtypes which can be homomeric or heteromeric, and are made up of the α7, α9 and α10 subunits; and 2) αBtgx-insensitive receptors, which are heteromeric combinations of α2–6 and β2–4 subunits that bind nicotine with high affinity but not αBgtx (Fig. 1B) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
nicotine | up-regulates activity
chemical activation
|
CHRNB3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264259 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28901280 |
Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are involved in a variety of physiological and pathophysiological processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Central Nervous System |
| + |
acetylcholine | up-regulates activity
chemical activation
|
CHRNB3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264258 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28901280 |
Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are involved in a variety of physiological and pathophysiological processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Central Nervous System |
| + |
CHRNB3 | up-regulates activity
binding
|
APC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264261 |
|
|
Homo sapiens |
Striated Muscle Cell |
| pmid |
sentence |
| 14502292 |
Treatment of muscle cells with neural agrin causes tyrosine phosphorylation of the AChR β subunit and induces AChR clustering by promoting anchoring of the receptor protein to postsynaptic cytoskeleton. Regulation of acetylcholine receptor clustering by the tumor suppressor APC. By showing a direct requirement for APC in AChR clustering, our present study suggests that the Wnt/β-catenin pathway may crosstalk with the agrin signaling cascade during the formation of mammalian neuromuscular junction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
CHRNB3
- 
- 