+ |
FYN | down-regulates
phosphorylation
|
ARHGAP33 |
0.473 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-147156 |
Tyr406 |
PLLTYQLyGKFSEAM |
Homo sapiens |
|
pmid |
sentence |
16777849 |
Tcgap interacted with fyn and was phosphorylated by fyn, with tyr-406 in the gap domain as a major fyn-mediated phosphorylation site. Fyn suppressed the gap activity of wild-type tcgap |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ARHGAP33 | down-regulates activity
gtpase-activating protein
|
RAC1 |
0.419 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260491 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
32203420 |
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |