3.0
Summary
| Name |  CFLARView Modifications |
| Full Name | CASP8 and FADD-like apoptosis regulator |
| Synonyms | Caspase homolog, CASH, Caspase-eight-related protein, Casper, Caspase-like apoptosis regulatory protein, CLARP, Cellular FLICE-like inhibitory protein, c-FLIP, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, I-FLICE, MACH-related inducer of toxicity, MRIT, Usurpin | CASH, CASP8AP1, CLARP, MRIT |
| Primary ID | O15519 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Function | Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCB | up-regulates quantity by stabilization 
phosphorylation
|
CFLAR | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCA | up-regulates quantity by stabilization
phosphorylation
|
CFLAR | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT | down-regulates quantity 
phosphorylation
|
CFLAR | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | down-regulates quantity
phosphorylation
|
CFLAR | 0.48 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CBL | down-regulates quantity by destabilization
ubiquitination
|
CFLAR | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RUNX3 | down-regulates quantity by repression 
transcriptional regulation
|
CFLAR | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK14 | up-regulates
phosphorylation
|
CFLAR | 0.381 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ITCH | down-regulates quantity
ubiquitination
|
CFLAR | 0.601 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | CFLAR | down-regulates activity
binding
|
CASP8 | 0.76 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Death Receptor Signaling | |||