4.0
Summary
| Name |  SPRY1
|
| Full Name | Protein sprouty homolog 1 |
| Synonyms | Spry-1 |
| Primary ID | O43609 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Pathways | Noonan syndrome |
| Function | Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SPRY1 | down-regulates 
binding
|
SOS1 | 0.386 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Noonan syndrome | |||
| + | PTPN11 | down-regulates
dephosphorylation
|
SPRY1 | 0.409 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Noonan syndrome | |||
| + | hsa-mir-132-3p | down-regulates quantity by repression
post transcriptional regulation
|
SPRY1 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |