3.0
Summary
| Name |  SOCS5
|
| Full Name | Suppressor of cytokine signaling 5 |
| Synonyms | SOCS-5, Cytokine-inducible SH2 protein 6, CIS-6, Cytokine-inducible SH2-containing protein 5 | CIS6, CISH5, CISH6, KIAA0671 |
| Primary ID | O75159 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. |
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