| + |
PTP4A3 | down-regulates activity 
dephosphorylation
|
KRT8 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248341 |
Ser432 |
SAYGGLTsPGLSYSL |
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 19115206 |
the cytoskeletal intermediate filament keratin 8 (KRT8) was identified as a physiological PRL-3-interacting protein. Indeed, treatment with the PRL-3 inhibitor effectively suppressed the phosphorylation of KRT8 at S73 and S431 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248340 |
Ser74 |
TVNQSLLsPLVLEVD |
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 19115206 |
the cytoskeletal intermediate filament keratin 8 (KRT8) was identified as a physiological PRL-3-interacting protein. Indeed, treatment with the PRL-3 inhibitor effectively suppressed the phosphorylation of KRT8 at S73 and S431|The site-specific phosphorylation of keratins induces the disassembly of these filaments, and the balance between their phosphorylation and dephosphorylation controls the continuous exchange of intermediate filament subunits between a soluble pool and polymerized filaments |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PTP4A3 | down-regulates activity
dephosphorylation
|
EZR |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248342 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 18078820 |
Here we report the identification of Ezrin as a specific and direct cellular substrate of PRL-3. In HCT116 colon cancer cell line, Ezrin was identified among the cellular proteins whose phosphorylation level decreased upon ectopic over-expression of wtPRL-3 but not of catalytically inactive PRL-3 mutants. Although PRL-3 over-expression in HCT116 cells appeared to affect Ezrin phosphorylation status at both tyrosine residues and Thr567, suppression of the endogenous protein by RNA interference pointed to Ezrin-Thr567 as the residue primarily affected by PRL-3 action. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | down-regulates activity
phosphorylation
|
PTP4A3 |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278262 |
Tyr53 |
VRVCEVTyDKTPLEK |
Homo sapiens |
|
| pmid |
sentence |
| 23691193 |
Our results show that Src kinase activity leads to the tyrosine phosphorylation of PRL-3, primarily on Y53.|Collectively these results support a model in which Src causes phosphorylation of PRL-3 on Y53 to promote its pro-invasion functions, and suggest for the first time that the metastasis-associated tyrosine phosphatase PRL-3 may itself be regulated by post-translational modification. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTP4A3 | down-regulates activity
dephosphorylation
|
ITGB1 |
0.529 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277050 |
Tyr783 |
DTGENPIyKSAVTTV |
Homo sapiens |
|
| pmid |
sentence |
| 23092334 |
In this study, we demonstrate that PRL-3 directly binds to integrin \u03b21 and dephosphorylates integrin \u03b21-Y783, a key residue for integrin \u03b21 function [ ].|These results indicate that PRL-3 dephosphorylates integrin \u03b21 in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTP4A3 | down-regulates quantity by destabilization
dephosphorylation
|
PTEN |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277010 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29266303 |
As expected, PRL3 clearly reduced PTEN phosphorylation at the tyrosine residue and PTEN protein in PRL3 overexpressing LO2 and HepG2 cell lines, with no significant changes in PRL3 (C104S) mutant cells.|PRL3 down-regulates PTEN expression, a negative regulator of the Akt pathway.11 Phosphorylation of PTEN at Tyr336 is required for maintenance of PTEN protein stability and prevention of PTEN degradation.17 We therefore speculated that PRL3 might dephosphorylate PTEN at tyrosine sites and consequently reduce the PTEN protein level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
PTP4A3
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