| + |
CSKMT | down-regulates activity 
methylation
|
CS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267637 |
Lys395 |
LLEQGKAkNPWPNVD |
|
|
| pmid |
sentence |
| 34929314 |
A mitochondrial matrix-located methyltransferase, methyltransferase-like protein 12 (METTL12), has been reported to methylate CS on the lysine 368 (K368) [15] and K395 residues [16] which are near the active site of CS. The methylation on K395 inhibits CS activity, which can be antagonized by its substrate oxaloacetate. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267638 |
Lys395 |
LLEQGKAkNPWPNVD |
|
|
| pmid |
sentence |
| 34929314 |
A mitochondrial matrix-located methyltransferase, methyltransferase-like protein 12 (METTL12), has been reported to methylate CS on the lysine 368 (K368) [15] and K395 residues [16] which are near the active site of CS. The methylation on K395 inhibits CS activity, which can be antagonized by its substrate oxaloacetate. |
|
| Publications: |
2 |
| + |
CS | down-regulates quantity
chemical modification
|
oxaloacetate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266549 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3013232 |
Citrate synthase catalyzes an important step within the cycle, the Claisen condensation of acetyl-Coenzyme A with oxaloacetate to form citrate; and it is the only enzyme in the cycle that can catalyze the formation of a carbon-carbon bond. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266239 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3013232 |
Citrate synthase catalyzes an important step within the cycle, the Claisen condensation of acetyl-Coenzyme A with oxaloacetate to form citrate; and it is the only enzyme in the cycle that can catalyze the formation of a carbon-carbon bond. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
CS | down-regulates quantity
chemical modification
|
acetyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266238 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3013232 |
Citrate synthase catalyzes an important step within the cycle, the Claisen condensation of acetyl-Coenzyme A with oxaloacetate to form citrate; and it is the only enzyme in the cycle that can catalyze the formation of a carbon-carbon bond. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
CS | up-regulates quantity 
chemical modification
|
citrate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266240 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3013232 |
Citrate synthase catalyzes an important step within the cycle, the Claisen condensation of acetyl-Coenzyme A with oxaloacetate to form citrate; and it is the only enzyme in the cycle that can catalyze the formation of a carbon-carbon bond. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
3.0
CS
- 
- 