+ |
ATR | up-regulates activity
phosphorylation
|
WDHD1 |
0.555 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262664 |
Thr826 |
KAAELTAtQVEEEEE |
Homo sapiens |
HCT-116 Cell |
pmid |
sentence |
26082189 |
And-1 is phosphorylated at T826 by ATR following replication stress, and this phosphorylation is required for And-1 to accumulate at the damage sites, where And-1 promotes the interaction between Claspin and Chk1, thereby stimulating efficient Chk1 activation by ATR. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
WDHD1 | up-regulates activity
binding
|
CLSPN |
0.401 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262665 |
|
|
Homo sapiens |
HCT-116 Cell |
pmid |
sentence |
26082189 |
And-1 is phosphorylated at T826 by ATR following replication stress, and this phosphorylation is required for And-1 to accumulate at the damage sites, where And-1 promotes the interaction between Claspin and Chk1, thereby stimulating efficient Chk1 activation by ATR. Significantly, And-1 binds directly to ssDNA and facilitates the association of Claspin with ssDNA. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |