| + |
ATM | up-regulates 
phosphorylation
|
NFAT5 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-125073 |
Ser1197 |
HIQTPMLsQEQAQPP |
Homo sapiens |
|
| pmid |
sentence |
| 15173573 |
Tonebp/orebp contains atm consensus phosphorylation sites at ser-1197, ser-1247, and ser-1367. In conclusion, signaling via atm is necessary for full activation of tonebp/orebp |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-125077 |
Ser1247 |
AMQSNSPsQEQQQQQ |
Homo sapiens |
|
| pmid |
sentence |
| 15173573 |
Tonebp/orebp contains atm consensus phosphorylation sites at ser-1197, ser-1247, and ser-1367. In conclusion, signaling via atm is necessary for full activation of tonebp/orebp |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-125081 |
Ser1367 |
LVQGSPSsQEQQVTL |
Homo sapiens |
|
| pmid |
sentence |
| 15173573 |
Tonebp/orebp contains atm consensus phosphorylation sites at ser-1197, ser-1247, and ser-1367. In conclusion, signaling via atm is necessary for full activation of tonebp/orebp |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CSNK1A1L | up-regulates activity
phosphorylation
|
NFAT5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274111 |
Ser158 |
LLDNSRMsCQDEGCG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18411282 |
However, the siRNA knockdown of CK1α1L significantly reduced the nuclear export of OREBP/TonEBP under hypotonic conditions (Fig. 5F). Taken together, these data suggest that CK1α1L is the kinase that phosphorylates Ser-158 in the regulation of OREBP/TonEBP export. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | up-regulates
phosphorylation
|
NFAT5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170882 |
Thr135 |
TVQQHPStPKRHTVL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21209322 |
High nacl-induced activation of cdk5 increases phosphorylation of the osmoprotective transcription factor tonebp/orebp at threonine 135, which contributes to its rapid nuclear localization. we performed in vitro kinase assays using the tonebp/orebp peptide containing t135 as substrate (figure 3b, right panel) and various recombinant kinases. The peptide is strongly phosphorylated by cdk5, less by cdk1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK5 | up-regulates
phosphorylation
|
NFAT5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170886 |
Thr135 |
TVQQHPStPKRHTVL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21209322 |
High nacl-induced activation of cdk5 increases phosphorylation of the osmoprotective transcription factor tonebp/orebp at threonine 135, which contributes to its rapid nuclear localization. n hek293 cells, mass spectrometry shows phosphorylation of tonebp/orebp-s120, -s134, -t135, and -s155. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN6 | down-regulates activity 
dephosphorylation
|
NFAT5 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248467 |
Tyr143 |
PKRHTVLyISPPPED |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20351292 |
We confirmed that SHP-1 is inhibitory by overexpressing it, which reduces TonEBP/OREBP transcriptional activity at 500 mosmol/kg. SHP-1 dephosphorylates TonEBP/OREBP at a known regulatory site, Y143, both in vivo and in vitro. It inhibits TonEBP/OREBP by both reducing TonEBP/OREBP nuclear localization, which is Y143 dependent, and by lowering high NaCl-induced TonEBP/OREBP transactivating activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFAT5 | up-regulates quantity by expression
transcriptional regulation
|
LCN2 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274114 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 22266867 |
As expected, the depletion of NFAT5 decreased the S100A4 and LCN2 mRNA levels (Figure 3a). In addition, chromatin immunoprecipitation (ChIP) assay using NFAT5 antibody indicated that NFAT5 was bound to the S100A4 and LCN2 promoters (Figure 3b, Supplementary Figure S3), as expected (Chen et al., 2009). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFAT5 | up-regulates quantity by expression
transcriptional regulation
|
S100A4 |
0.491 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274115 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 22266867 |
As expected, the depletion of NFAT5 decreased the S100A4 and LCN2 mRNA levels (Figure 3a). In addition, chromatin immunoprecipitation (ChIP) assay using NFAT5 antibody indicated that NFAT5 was bound to the S100A4 and LCN2 promoters (Figure 3b, Supplementary Figure S3), as expected (Chen et al., 2009). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNA helicases DDX5/DDX17 | up-regulates activity
binding
|
NFAT5 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274113 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 22266867 |
In this work, we report that ddx5 and ddx17 have a dual role in the control of the pro-migratory NFAT5 transcription factor. First, ddx5 and ddx17 act as transcriptional coactivators of NFAT5 and are required for activating NFAT5 target genes involved in tumor cell migration. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274112 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 22266867 |
In this work, we report that ddx5 and ddx17 have a dual role in the control of the pro-migratory NFAT5 transcription factor. First, ddx5 and ddx17 act as transcriptional coactivators of NFAT5 and are required for activating NFAT5 target genes involved in tumor cell migration. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
NFAT5
- 
- 