Summary

Name ABCA1
Full Name Phospholipid-transporting ATPase ABCA1
Synonyms ATP-binding cassette transporter 1, ABC-1, ATP-binding cassette 1, Cholesterol efflux regulatory protein | ABC1, CERP
Primary ID O95477
Links - -
Type protein
Relations 9
Function Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Thereby, participates in phospholipid transfer to apoliproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PRKACAup-regulates activity img/direct-activation.png phosphorylation ABCA1 0.485
Publications: 2 Organism: Mus Musculus
+ EGFRdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ABCA1 0.299
Publications: 1 Organism: Homo Sapiens
+ APOA1up-regulates quantity by stabilization img/direct-activation.png binding ABCA1 0.783
Publications: 1 Organism: Homo Sapiens
+ ABCA1up-regulates activity img/direct-activation.png binding MEGF10 0.339
Publications: 1 Organism: Homo Sapiens
+ ABCA1up-regulates img/indirect-activation.png HDL_assembly 0.7
Publications: 1 Organism: Homo Sapiens
+ MEGF10up-regulates activity img/direct-activation.png binding ABCA1 0.339
Publications: 1 Organism: Homo Sapiens
+ LNX1down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ABCA1 0.243
Publications: 1 Organism: In Vitro
+ ABCA1up-regulates activity img/direct-activation.png binding APOA1 0.783
Publications: 1 Organism: Homo Sapiens