3.0
Summary
| Name |  MAP4K4View Modifications |
| Full Name | Mitogen-activated protein kinase kinase kinase kinase 4 |
| Synonyms | HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase | HGK, KIAA0687, NIK |
| Primary ID | O95819 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAP4K4 | down-regulates activity 
phosphorylation
|
SMAD1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP4K4 | up-regulates activity 
phosphorylation
|
MAP3K11 | 0.309 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP4K4 | up-regulates
binding
|
MAP3K7 | 0.563 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP4K4 | up-regulates
phosphorylation
|
MAP3K1 | 0.538 |
| Publications: | 1 | Organism: | Homo Sapiens | |